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Table 5 Within-patient change threshold analyses: Mean change from baseline by anchor-based methods for E-RS Total and domain scores and wheeze item

From: Reliability, validity and responsiveness of E-RS:COPD in patients with spirometric asthma-COPD overlap

Item Subgroup Mean change from baseline to final weeka (SD)
RS-Total Global impression of change: slightly better (n = 129) −1.4 (3.4)
Global impression of change: slightly worse (n = 14) 0.2 (3.7)
SGRQ improvement: decrease 4 to 5 points (n = 8) −2.7 (3.4)
SGRQ deterioration: increase 4 to 5 points (n = 11) −1.4 (2.9)
RS-Cough and Sputum Global impression of change: slightly better (n = 129) −0.3 (1.2)
Global impression of change: slightly worse (n = 14) 0.0 (1.4)
SGRQ improvement: decrease 4 to 5 points (n = 8) −0.7 (0.6)
SGRQ deterioration: increase 4 to 5 points (n = 11) 0.3 (0.6)
RS-Chest Symptoms Global impression of change: slightly better (n = 129) −0.4 (1.1)
Global impression of change: slightly worse (n = 14) 0.5 (1.4)
SGRQ improvement: decrease 4 to 5 points (n = 8) −0.8 (1.4)
SGRQ deterioration: increase 4 to 5 points (n = 11) −0.6 (1.2)
RS-Breathlessness Global impression of change: slightly better (n = 129) −0.7 (1.6)
Global impression of change: slightly worse (n = 14) −0.3 (1.4)
SGRQ improvement: decrease 4 to 5 points (n = 8) −1.2 (1.6)
SGRQ deterioration: increase 4 to 5 points (n = 11) −0.5 (1.4)
Wheeze Global impression of change: slightly better (n = 129) −0.1 (0.5)
Global impression of change: slightly worse (n = 14) −0.1 (0.6)
SGRQ improvement: decrease 4 to 5 points (n = 8) −0.2 (0.6)
SGRQ deterioration: increase 4 to 5 points (n = 11) −0.2 (0.5)
  1. aThe baseline week was defined as the last week of run-in (Day −7 to Day −1). The final week was defined as the final week of the 4-week treatment period (Day 21 to Day 28)
  2. E-RS Evaluating Respiratory Symptoms in chronic obstructive pulmonary disease, SD standard deviation, SGRQ St George’s Respiratory Questionnaire