Table 5 Within-patient change threshold analyses: Mean change from baseline by anchor-based methods for E-RS Total and domain scores and wheeze item
Item | Subgroup | Mean change from baseline to final weeka (SD) |
|---|---|---|
RS-Total | Global impression of change: slightly better (n = 129) | −1.4 (3.4) |
Global impression of change: slightly worse (n = 14) | 0.2 (3.7) | |
SGRQ improvement: decrease 4 to 5 points (n = 8) | −2.7 (3.4) | |
SGRQ deterioration: increase 4 to 5 points (n = 11) | −1.4 (2.9) | |
RS-Cough and Sputum | Global impression of change: slightly better (n = 129) | −0.3 (1.2) |
Global impression of change: slightly worse (n = 14) | 0.0 (1.4) | |
SGRQ improvement: decrease 4 to 5 points (n = 8) | −0.7 (0.6) | |
SGRQ deterioration: increase 4 to 5 points (n = 11) | 0.3 (0.6) | |
RS-Chest Symptoms | Global impression of change: slightly better (n = 129) | −0.4 (1.1) |
Global impression of change: slightly worse (n = 14) | 0.5 (1.4) | |
SGRQ improvement: decrease 4 to 5 points (n = 8) | −0.8 (1.4) | |
SGRQ deterioration: increase 4 to 5 points (n = 11) | −0.6 (1.2) | |
RS-Breathlessness | Global impression of change: slightly better (n = 129) | −0.7 (1.6) |
Global impression of change: slightly worse (n = 14) | −0.3 (1.4) | |
SGRQ improvement: decrease 4 to 5 points (n = 8) | −1.2 (1.6) | |
SGRQ deterioration: increase 4 to 5 points (n = 11) | −0.5 (1.4) | |
Wheeze | Global impression of change: slightly better (n = 129) | −0.1 (0.5) |
Global impression of change: slightly worse (n = 14) | −0.1 (0.6) | |
SGRQ improvement: decrease 4 to 5 points (n = 8) | −0.2 (0.6) | |
SGRQ deterioration: increase 4 to 5 points (n = 11) | −0.2 (0.5) |