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Table 1 Hemodynamic measurements

From: Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

 

Control

LPS

NS

norNOHA

(40mg/kg)

NS

norNOHA

(20mg/kg)

norNOHA

(40mg/kg)

HR

(bpm)

 Baseline

593±50

619±57

605±61

651±54

631±62

 LMBO

584±44

626±71

603±50

634±74

636±68

SAP

(mmHg)

 Baseline

93±18

97±11

96±14

95±7

102±4

 LMBO

91±12

77±7A*

93±16*

92±9

101±6

PAP

(mmHg)

 Baseline

17±2

17±1

18±2

16±2

17±1

 LMBO

19±1*

19±1*

20±1*

19±4*

20±2*

QLPA

(ml/min)

 Baseline

2.3±0.3

2.6±0.5

2.8±0.4

2.9±0.9

2.4±0.3

 LMBO

1.4±0.2*

1.9±0.5*

2.3±0.4B*

2.6±1.0AB

1.6±0.3*

  1. Hemodynamic parameters before (baseline) and during left mainstem bronchus occlusion (LMBO) in wild-type mice 22 h after challenge with saline (control) or endotoxin (LPS). One hour prior to the measurement, mice were treated with normal saline (NS) or with the arginase inhibitor Nω-hydroxy-nor-Arginine (norNOHA). N = 7 per group
  2. HR heart rate, SAP systemic arterial pressure, PAP pulmonary arterial pressure, QLPA flow rate in the left pulmonary artery, bpm beats per minute, mmHg millimeters of mercury, and ml/min milliliter per minute
  3. Data are presented as mean ± SD. A P < 0.05 vs. LPS norNOHA 40 mg/kg, B P < 0.05 vs. control NS, * P < 0.05 vs. baseline
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Respiratory Research

ISSN: 1465-993X

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