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Table 1 Hemodynamic measurements

From: Arginase impairs hypoxic pulmonary vasoconstriction in murine endotoxemia

  Control LPS
NS norNOHA
(40mg/kg)
NS norNOHA
(20mg/kg)
norNOHA
(40mg/kg)
HR
(bpm)
 Baseline 593±50 619±57 605±61 651±54 631±62
 LMBO 584±44 626±71 603±50 634±74 636±68
SAP
(mmHg)
 Baseline 93±18 97±11 96±14 95±7 102±4
 LMBO 91±12 77±7A* 93±16* 92±9 101±6
PAP
(mmHg)
 Baseline 17±2 17±1 18±2 16±2 17±1
 LMBO 19±1* 19±1* 20±1* 19±4* 20±2*
QLPA
(ml/min)
 Baseline 2.3±0.3 2.6±0.5 2.8±0.4 2.9±0.9 2.4±0.3
 LMBO 1.4±0.2* 1.9±0.5* 2.3±0.4B* 2.6±1.0AB 1.6±0.3*
  1. Hemodynamic parameters before (baseline) and during left mainstem bronchus occlusion (LMBO) in wild-type mice 22 h after challenge with saline (control) or endotoxin (LPS). One hour prior to the measurement, mice were treated with normal saline (NS) or with the arginase inhibitor Nω-hydroxy-nor-Arginine (norNOHA). N = 7 per group
  2. HR heart rate, SAP systemic arterial pressure, PAP pulmonary arterial pressure, QLPA flow rate in the left pulmonary artery, bpm beats per minute, mmHg millimeters of mercury, and ml/min milliliter per minute
  3. Data are presented as mean ± SD. A P < 0.05 vs. LPS norNOHA 40 mg/kg, B P < 0.05 vs. control NS, * P < 0.05 vs. baseline