Table 4 Comparison of decline in functional outcomes and in health status between groups with fast and slower decline in health status
| Â | Fast decline | Slower decline | p |
|---|---|---|---|
(n = 31) | (n = 152) |  | |
Lung function | |||
 ∆ FEV1 (liter) | −0.04 [− 0.05 – − 0.02] | -0.02 [− 0.05–0.00] | 0.09 |
 ∆ FRC (liter) | 0.027 [− 0.047–0.086] | 0.009 [−0.036–0.064] | 0.74 |
 ∆ TL,CO (ml/min/kPa) | − 0.047 [− 0.220 – − 0.010] | −0.067 [− 0.173–0.010] | 0.74 |
Physical fitness | |||
 ∆ BMI (kg/m2) | 0.06 [− 0.10–0.26] | 0.09 [− 0.06–0.24] | 0.88 |
 ∆ FFM (% body weight) | −0.49 [− 0.77 – − 0.17] | −0.22 [− 0.45–0.03] | 0.02 |
 ∆ Handgrip (kg) | −0.49 [− 1.29 – − 0.11] | −0.33 [− 0.83–0.21] | 0.08 |
 ∆ Quadriceps force (Nm) | −3.83 [− 6.07 – − 1.92] | −3.20 [− 6.56 – − 0.57] | 0.61 |
 ∆ 6MWD (meter) | −7.27 [− 13.02 – − 1.00] | − 2.12 [− 6.94–3.26] | < 0.01 |
 ∆ VO2peak (l/min) | −0.06 [− 0.10 – − 0.02] | −0.075 [− 0.13 – − 0.03] | 0.50 |
 ∆ OUES (slope) | − 45 [− 103–7] | − 57 [− 116 – − 2] | 0.58 |
Physical activity | |||
 ∆ Steps/day | − 222 [− 591 – − 66] | − 268 [− 525–92] | 0.72 |
 ∆ MVPA (minutes) | −2.72 [− 6.50–3.92] | −1.38 [− 7.86–4.21] | 0.89 |
Emotional state | |||
 ∆ HADS anxiety (score) | 0.32 [−0.03–0.56] | −0.08 [− 0.33–0.13] | < 0.0001 |
 ∆ HADS depression (score) | 0.28 [0.00–0.81] | 0.00 [− 0.17–0.16] | < 0.001 |
Health status | |||
 ∆ SF36 PCS (sum score) | −3.02 [− 5.13 – − 2.13] | 0.02 [− 0.89–0.59] | < 0.0001 |
 ∆ SF36 MCS (sum score) | −2.38 [− 4.88 – − 0.95] | 0.14 [− 0.47–0.76] | < 0.0001 |
 ∆ EQ-5D VAS (score) | −2.49 [− 4.57 – − 1.18] | 0 [− 0.73–0.84] | < 0.0001 |
 ∆ CCQ (total score) | 0.100 [0.050–0.177] | 0.007 [− 0.020–0.039] | < 0.0001 |