Skip to main content
Fig. 5 | Respiratory Research

Fig. 5

From: Bradykinin sensitizes the cough reflex via a B2 receptor dependent activation of TRPV1 and TRPA1 channels through metabolites of cyclooxygenase and 12-lipoxygenase

Fig. 5

Effect of i.c.v. co-administration of TRPV1 channel antagonist, JNJ-17203212 (JNJ) 1 μmole ml− 1 and TRPA1 channel antagonist, HC-030031 (HC) 60 nmole ml− 1 (n = 5), versus vehicle (n = 5), on BK-enhanced citric acid-induced cough (a) changes in Penh (b) and Penh AUC (c). Values represent means + sem. * p < 0.05; ** p < 0.01; *** p < 0.001, significant difference compared to vehicle/BK treated animals

Back to article page

Respiratory Research

ISSN: 1465-993X

Contact us