Table 4 Estimated delivered and respirable doses upon nebulization of 200 mg of IgG. Breath simulation experiments and laser diffraction measurements were conducted upon nebulization of 2 ml (200 mg) of IgG to measure delivered and respirable doses (RD)
From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates
Formulation | Nebulized dose (mg) | Residue (%) | Delivered dose (mg) | Delivered dose (%) | RD < 5 μm (mg) | RD < 5 μm (%) |
|---|---|---|---|---|---|---|
IgG 10% | 200 | 32.7 ± 8.10 | 94.06 ± 18.14 | 45.4 ± 9.00 | 72.24 ± 13.64 | 34.91 ± 6.78 |
IgG 5% | 100 | 33 ± 9.10 | 49.36 ± 7.37 | 47.7 ± 7.10 | 34.36 ± 4.91 | 33.21 ± 4.74 |
IgA 5% | 100 | 30.4 ± 6.90 | 48.41 ± 6.73 | 48.9± 6.90 | 35.33 ± 4.59 | 35.69 ± 4.63 |
IgAM 5% | 100 | 30.8 ± 6.00 | 50.92 ± 6.32 | 51.4 ± 6.30 | 38.96 ± 5.37 | 39.34 ± 5.29 |