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Table 4 Estimated delivered and respirable doses upon nebulization of 200 mg of IgG. Breath simulation experiments and laser diffraction measurements were conducted upon nebulization of 2 ml (200 mg) of IgG to measure delivered and respirable doses (RD)

From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

Formulation Nebulized dose (mg) Residue (%) Delivered dose (mg) Delivered dose (%) RD < 5 μm (mg) RD < 5 μm (%)
IgG 10% 200 32.7 ± 8.10 94.06 ± 18.14 45.4 ± 9.00 72.24 ± 13.64 34.91 ± 6.78
IgG 5% 100 33 ± 9.10 49.36 ± 7.37 47.7 ± 7.10 34.36 ± 4.91 33.21 ± 4.74
IgA 5% 100 30.4 ± 6.90 48.41 ± 6.73 48.9± 6.90 35.33 ± 4.59 35.69 ± 4.63
IgAM 5% 100 30.8 ± 6.00 50.92 ± 6.32 51.4 ± 6.30 38.96 ± 5.37 39.34 ± 5.29