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Table 3 Pharmacokinetic study design, characteristics and immediate post dose (IPD) BAL Ig recovery. For the NHP study, isotype measured by LC-MS is indicated into brackets

From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates

Species Product Overall Estimated Delivered Dose Level (mg/kg/day) Highest IPD BAL recovery (μg)
Rat Vehicle N/A N/A
IgG 5% 31.7 4.2
IgA 5% 32.66 2.4
IgAM 5% 38.54 10.7
NHP Vehicle N/A N/A
IgG 5% 29.6 4368.4 (IgG1)
IgA 5% 25.8 2454.6 (IgA1)
IgAM 5% 25.6 4130.1 (IgA1)
1723.9 (IgM)