Fig. 5
From: Topical application of nebulized human IgG, IgA and IgAM in the lungs of rats and non-human primates
Topically applied human plasma-derived IgG protect mice against death in an acute S. pneumoniae infection model. Binding of IgG, IgA and IgAM preparations to S. pneumoniae A66.1 bacteria was assessed by ELISA (a). Survival of C57BL/6 WT and human CD89Tg mice infected with 5 × 105 A66.1 S. pneumoniae at Day 0 (b). Vehicle or Ig preparations were given a day prior infection. N = 8 mice/group