Hazard ratio | 95% CI | p value | |
---|---|---|---|
Age, years | 1.053 | 1.040–1.066 | < 0.001 |
Male sex compared to female | 3.215 | 2.255–4.583 | < 0.001 |
Body mass index | 0.859 | 0.827–0.893 | < 0.001 |
Ever-smoker | 2.075 | 1.569–2.746 | < 0.001 |
mMRC dyspnea scale | < 0.001 | ||
0 (reference) | 1.000 | ||
1 | 1.497 | 1.074–2.085 | 0.017 |
2 | 1.742 | 1.177–2.578 | 0.006 |
3 | 3.139 | 2.127–4.633 | < 0.001 |
4 | 3.646 | 2.235–5.947 | < 0.001 |
Charlson Comorbidity Index | 1.234 | 1.180–1.290 | < 0.001 |
Concomitant asthma | 0.980 | 0.613–1.566 | 0.932 |
Concomitant COPD | 1.738 | 1.049–1.784 | 0.021 |
ICS/LABA usage | 0.849 | 0.582–1.238 | 0.394 |
FEV1, % predicted | 0.981 | 0.975–0.987 | < 0.001 |
FVC, % predicted | 0.971 | 0.965–0.978 | <.001 |
FEV1/FVC ratio, % | 0.996 | 0.989–1.004 | 0.316 |
DLco, % predicted | 0.963 | 0.953–0.973 | <.001 |
X-ray severity (0 to 6) | 1.618 | 1.471–1.780 | < 0.001 |
Long-term oxygen therapy | 2.036 | 1.380–3.004 | < 0.001 |