Aminoguanidine affects systemic and lung inflammation induced by lipopolysaccharide in rats

Respiratory Research

Table 1 Percent changes of various measured parameters in LPS relative to control and in AG treated relative to LPS groups (%)

Parameters	Sample	LPS/Ctrl	AG/LPS
Parameters	Sample	LPS/Ctrl	50	100	150
Total nitrite concentration	Serum	238	93	79	57
Total nitrite concentration	BALF	125	78	78	69
Total WBC count	Blood	141	91	85	77
Total WBC count	BALF	182	97	86	73
Neutrophils	Blood	138	87	83	80
Neutrophils	BALF	126	100	92	95
Lymphocytes	Blood	142	93	86	75
Lymphocytes	BALF	175	97	88	74
Monocytes	Blood	155	88	82	73
Macrophages	BALF	320	96	78	56
Eosinophils	Blood	109	108	100	91
Eosinophils	BALF	150	85	100	83
MDA concentration	Serum	240	86	62	53
MDA concentration	BALF	623	71	68	44
Total thiol content	Serum	26	106	162	232
Total thiol content	BALF	16	86	124	368
SOD activity	Serum	10	292	370	585
SOD activity	BALF	13	295	468	528
CAT activity	Serum	33	133	165	214
CAT activity	BALF	8	263	398	583
IL-4	BALF	42	101	155	222
IFN-γ	BALF	293	82	70	45
TGF-β1	BALF	281	86	73	46
PGE2	BALF	301	79	68	42
Interstitial inflammation	Lung tissue	732	100	90	63
Lymphoid infiltration	Lung tissue	666	79	75	49

ISSN: 1465-993X