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Fig. 8 | Respiratory Research

Fig. 8

From: The cullin4A is up-regulated in chronic obstructive pulmonary disease patient and contributes to epithelial-mesenchymal transition in small airway epithelium

Fig. 8

The expression of CUL4A is associated with an increase in the level of H3K4me3 on the Slug promoter. a Detection of histone modification after overexpression of CUL4A revealed that H3K4me3 was affected by overexpression of CUL4A. b Schematic presentation of three regions relative to the Slug transcriptional start site used as primers to test H3K14me3 occupied abundance. c ChIP-qPCR was performed to assess H3K4me3 occupancy to Slug transcriptional start site in HSAEpiC-CUL4A and its control cells. IgG was used as negative control. d Slug gene promoter luciferase assay was further confirmed. **P < 0.01 (in c and d) is based on Student’s t-test. Error bars indicate standard deviation

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Respiratory Research

ISSN: 1465-993X

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