Skip to main content

Table 2 CPET-related variables

From: The value of high-resolution computed tomography (HRCT) to determine exercise ventilatory inefficiency and dynamic hyperinflation in adult patients with cystic fibrosis

Variables

Study sample n = 52

Patients with Vef and without DH

Patients with Vin and without DH

Patients with Vef and with DH

Patients with Vin and with DH

p value a

V’O2 at peak, ml/kg/min

28.1 ± 8.2

31.0 ± 7.7

25.8 ± 7.3

30.7 ± 9.2

25.7 ± 7.9

0.180

Workload, watts

121 [97; 169]

168 [121; 216.5]

109 [98; 146.5]

127.5 [94.5; 188]

102 [88; 138]

0.067

Δ IC, L

− 0.19 [− 0.43; 0.15]

0.24 [− 0.05; 0.37]

0.16 [0.08; 0.55]

−0.43 [− 0.54; − 0.21] c e

−0.38 [− 0.43; − 0.26] c e

< 0.001

Δ VT, L

0.89 [0.51; 1.33]

1.34 [0.95; 1.61]

0.92 [0.44; 1.24]

0.88 [0.57; 1.19] b

0.64 [0.29; 0.89] b

0.039

RR at peak, breath/min

37 [32; 44]

34 [32.1; 41.5]

31 [28; 38.9]

38.8 [31.7; 42.5]

44 [36; 51]

0.073

V’E/V’CO2 at rest

43.4 ± 5.9

39.8 ± 5.1

42.1 ± 5.0

43.4 ± 5.3

46.9 ± 6.2 b

0.017

V’E/V’CO2 slope

29.3 ± 4.8

25.6 ± 1.9

33.0 ± 4.4 c

24.9 ± 2.7 e

32.5 ± 2.3 c g

< 0.001

V’E/V’CO2 intercept, L∙min− 1

3.28 [1.95; 4.33]

3.3 [2.5; 3.6]

0.8 [0.2; 2.6] b

4 [3.2; 7.4] b d

3.6 [2.6; 5] d

0.001

O2 pulse at rest, mL/beat/min

3.2 [2.3; 3.9]

3.3 [2.1; 4.5]

3.3 [2.1; 3.9]

3 [2.5; 3.9]

3.3 [2.3; 3.9]

0.948

Δ O2 pulse, mL/beat/min

7.0 ± 2.6

8.8 ± 2.7

6.0 ± 2.1 b

7.9 ± 3.0

5.9 ± 1.5 b

0.008

Δ PETCO2

6 [4; 9]

6.5 [4.7; 8]

3 [0.5; 6]

10 [6.7; 14] b e

6 [3; 7] f

0.001

HR recovery

23 [15.2; 28]

25 [21.7; 31]

23 [15.5; 27.5]

20.5 [14.2; 24.5]

23 [13; 29]

0.261

HR/VO2

56 [46; 65.7]

47.5 [41.7; 59]

59 [47.5; 74]

50 [42; 64.2]

62 [52; 73]

0.122

DP reserve

15,251.1 ± 4192.6

15,387.0 ± 5090.4

14,966.5 ± 3391.4

15,063.2 ± 4187.2

15,582.7 ± 4582.2

0.980

DP reserve/Workload

123.8 ± 35.8

97.1 ± 36.1

129.9 ± 36.3

117.4 ± 27.9

142.3 ± 31.9 b

0.011

SpO2 at rest, %

96.7 ± 1.7

97.3 ± 1.9

97.5 ± 1.3

96.4 ± 1.8

95.9 ± 1.7

0.079

Δ SpO2, %

−2.0 ± 3.3

−0.6 ± 2.5

−1.1 ± 2.7

−3.9 ± 3.8

− 2.0 ± 3.4

0.065

Peak dyspnea

0.51 [0.39; 0.77]

0.43 [0.25; 0.62]

0.55 [0.44; 0.73]

0.52 [0.36; 0.88]

0.57 [0.45; 0.95]

0.384

Peak fatigue

0.65 [0.45; 0.82]

0.47 [0.38; 0.77]

0.74 [0.60; 0.88]

0.60 [0.34; 0.77]

0.71 [0.57; 0.91]

0.198

  1. Data are shown as number of patients (%), means ± SD or medians [1st quartile; 3rd quartile], unless otherwise stated
  2. Variables with Δ were calculated as peak-to-rest changes
  3. Abbreviations: V’O2 oxygen uptake, IC inspiratory capacity, VT tidal volume, RR respiratory rate, V’E minute ventilation, V’CO2 carbon dioxide output, PETCO2 end-tidal pressure of CO2, HR heart rate, DP double product, SpO2 oxygen saturation
  4. Peak dyspnea and peak fatigue were described as visual analogic scale (VAS) with 0–100 score and peak workload ratio
  5. ap-value calculated between all groups
  6. bp-value < 0.05 versus patients with Vef and without DH
  7. cp-value < 0.001 versus patients with Vef and without DH
  8. dp-value < 0.05 versus patients with Vin and without DH
  9. ep-value < 0.001 versus patients with Vin and without DH
  10. fp-value < 0.05 versus patients with Vef and with DH
  11. gp-value < 0.001 versus patients with Vef and with DH
  12. Boldface variables are statistically significants