Table 1 Demographic characteristics of COPD subjects and controls
Parameter | Smoking controls | Never-smoking controls | COPD | P value |
|---|---|---|---|---|
n | 95 | 95 | 95 | |
Age, mean (SD) | 59.4 (7.2) | 58.8 (7.6) | 60.0 (6.4) | 0.663 ¥ |
Female gender, n (%) | 47 (49%) | 47 (49%) | 47 (49%) | 1.000 £ |
BMI, mean (SD) | 27.4 (4.3) | 28.4 (4.5) | 27.4 (5.5) | 0.239 ¥ |
Pack-years, median (IQR) | 30 (18–40) | 0 (0–0) | 38 (30–48) | < 0.0001 ¥ |
Current smokers, n (%) | 47 (49%) | 0 (0%) | 47 (49%) | < 0.0001 £ |
Cardiovascular history, n (%) | 26 (27%) | 16 (17%) | 21 (22%) | 0.217 £ |
Post bronchodilator FEV1 (% predicted), mean (SD) | 110.3 (13.6) | 114.0 (13.7) | 53.3 (15.6) | < 0.0001 ¥ |
C4Ma3 (ng/mL), median (IQR) | 3.04 (2.44–3.85) | 2.76 (2.20–3.35) | 3.12 (2.46–4.22) | 0.0047 ¥ |
TUM (ng/mL), median (IQR) | 0.71 (0.64–0.78) | 0.63 (0.60–0.73) | 0.73 (0.63–0.80) | 0.263 ¥ |
Fibrinogen (mg/dL), median (IQR) | 343.4 (311.0–383.6) | 326.6 (287.7–375.8) | 356.4 (318.8–421.2) | 0.0009 ¥ |