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Table 3 Unadjusted and adjusted correlation of ILD severity with body composition

From: Body composition, muscle function, and physical performance in fibrotic interstitial lung disease: a prospective cohort study

  Unadjusted analysis Adjusted for sex, age, weight
Men Women
r p-value r p-value Coefficient (95% CI) p-value R2
SMI, kg/m2
 FVC, %-predicted 0.22 0.07 −0.06 0.71 0.012 (0.005 to 0.018) 0.0006 0.75
 DLCO, %-predicted 0.39 0.002 0.15 0.40 0.013 (0.006 to 0.021) 0.0009 0.76
 CPI −0.40 0.002 −0.19 0.27 −0.016 (− 0.026 to − 0.007) 0.0001 0.76
 Dyspnea (UCSD SOBQ) − 0.08 0.57 0.29 0.09 −0.004 (− 0.010 to 0.002) 0.19 0.74
Body fat, %
 FVC, %-predicted −0.37 0.002 −0.30 0.04 −0.063 (− 0.105 to − 0.020) 0.004 0.70
 DLCO, %-predicted 0.03 0.79 0.12 0.51 0.001 (−0.050 to 0.052) 0.96 0.68
 CPI 0.05 0.68 −0.06 0.74 0.025 (−0.036 to 0.087) 0.42 0.69
 Dyspnea (UCSD SOBQ) 0.41 0.003 0.28 0.09 0.021 (−0.017 to 0.060) 0.28 0.70
  1. Coefficients are reported per one-unit change for the predictor variables. A positive coefficient indicates an increase in the outcome variable per unit of the predictor variable (e.g., SMI increases by an average of 0.012 kg/m2 for every 1% increase of FVC %-predicted)
  2. Abbreviations: CI confidence interval, CPI Composite Physiologic Index, C diffusion capacity of the lung for carbon monoxide, FVC forced vital capacity, r Pearson’s correlation coefficient, R2 coefficient of determination (variability in the outcome explained by the model), SMI skeletal muscle index, UCSD SOBQ University of California San Diego Shortness of Breath Questionnaire