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Table 2 Studies reporting immune cell infiltration in COPD SAD

From: The pathology of small airways disease in COPD: historical aspects and future directions

Authors Key findings Area of quantification / Type of analysis Patient groups
Macrophages Neutrophils CD3+ CD4+ CD8+ CD20+
Saetta et al. 1998 [76] = = NQ = NQ Sub-epithelium excluding smooth muscle COPD vs S
Saetta et al. 2000 [59] = NQ = NQ Intra-epithelium COPD vs NS
Turato et al. 2002 [77] a = NQ b b NQ aIntra- and bsub-epithelium GOLD 3 vs S and GOLD 1
Hogg et al. 2004 [22] a a NQ a a, b a, b aNumber of airways +ve for cell type
bAccumulated volume
Increasing severity of disease
Baraldo et al. 2004 [82] = a, b NQ = a, b NQ aWithin smooth muscle bpercentage of airways +ve for cell type COPD vs NS
Pilette et al. 2007 [80] = NQ NQ NQ Intra-epithelium and lamina propria COPD vs S
Battaglia et al. 2007 [83] = a = = = NQ Lamina propria adid not reach significance COPD vs S
Kim et al. 2008 [84] = = = = NQ Intra- and sub-epithelium GOLD 4 vs GOLD 0
Olloquequi et al. 2010 [81] NQ NQ = = = Intra- and sub-epithelium GOLD2 vs NS
Isajevs et al. 2011[79] NQ NQ NQ Intra- and sub-epithelium COPD vs NS
Polosukhin et al. 2011 [27] NQ NQ NQ = NQ Intra- and sub-epithelial COPD vs NS
Polosukhin et al. 2017 [26] NQ NQ NQ NQ Sub-epithelium COPD vs NS
GOLD 3/4 vs GOLD 1/2
Eapen et al. 2017 [78] = = NQ NQ NQ Sub-epithelium COPD vs NS
  1. ↑: increase in cell number; =: no difference
  2. NQ not quantified, NS never smoker, S smoker without COPD, GOLD global initiative for chronic obstructive lung disease
  3. "The meaning of a/b are described in the 'area of quantification/type of analysis' column."