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Table 2 Meta-analysis of the association between ADAM33 genetic polymorphisms and asthma risk in total population and subgroup analysis by ethnicities and ages

From: Association between ADAM33 polymorphisms and asthma risk: a systematic review and meta-analysis

SNPs

Comparisons

N

Test of association

Test of heterogeneity

OR (95%CI)

P

Ph

I2(%)

Model

T + 1 (rs2280089)

 G/A

A vs. G

10

1.18 (0.87, 1.60)

0.27

< 0.00001

80

R

AA vs. GG

 

1.55 (1.01, 2.38)

0.04

0.44

0

F

AG vs. GG

 

1.23 (0.87, 1.74)

0.24

< 0.00001

79

R

AA+AG vs. GG

 

1.23 (0.87, 1.74)

0.25

< 0.00001

80

R

AA vs. AG + GG

 

1.37 (0.89, 2.10)

0.15

0.55

0

F

 Asians

A vs. G

8

1.32 (0.96, 1.81)

0.09

< 0.0001

80

R

AA+AG vs. GG

 

1.38 (0.96, 1.99)

0.08

< 0.00001

80

R

 Children

A vs. G

4

1.16 (0.54, 2.49)

0.71

< 0.00001

90

R

AA+AG vs. GG

 

1.17 (0.51, 2.69)

0.71

< 0.00001

89

R

T1 (rs2280091)

 A/G

G vs. A

34

1.10 (0.90, 1.34)

0.34

< 0.00001

88

R

GG vs. AA

 

1.24 (0.83, 1.86)

0.30

< 0.00001

71

R

AG vs. AA

 

1.13 (0.91, 1.39)

0.26

< 0.00001

82

R

GG + AG vs. AA

 

1.14 (0.91, 1.43)

0.26

< 0.00001

87

R

GG vs. AG + AA

 

1.15 (0.83, 1.60)

0.40

< 0.00001

65

R

 Asians

G vs. A

27

0.83 (0.65, 1.05)

0.13

< 0.00001

89

R

GG + AG vs. AA

 

1.24 (0.94, 1.65)

0.13

< 0.00001

88

R

 Caucasians

G vs. A

6

1.11 (0.97, 1.28)

0.14

0.15

38

F

GG + AG vs. AA

 

0.89 (0.76, 1.05)

0.16

0.12

43

F

 Children

G vs. A

12

1.18 (0.83, 1.66)

0.36

< 0.00001

88

R

GG + AG vs. AA

 

1.41 (0.98, 2.04)

0.07

< 0.00001

83

R

 Adults

G vs. A

6

0.76 (0.53, 1.08)

0.13

0.0007

76

R

GG + AG vs. AA

 

0.82 (0.51, 1.31)

0.40

< 0.0001

84

R

T2 (2280090)

 G/A

A vs. G

29

1.32 (1.08, 1.60)

0.006

< 0.00001

86

R

AA vs. GG

 

1.77 (1.09, 2.87)

0.02

< 0.00001

68

R

AG vs. GG

 

1.25 (1.03, 1.52)

0.02

< 0.00001

80

R

AA+AG vs. GG

 

1.30 (1.06, 1.61)

0.01

< 0.00001

84

R

AA vs. AG + GG

 

1.62 (1.07, 2.46)

0.02

< 0.00001

57

R

 Asians

A vs. G

24

1.44 (1.13, 1.85)

0.004

< 0.00001

88

R

AA+AG vs. GG

 

1.45 (1.11, 1.88)

0.006

< 0.00001

86

R

Caucasians

A vs. G

4

0.93 (0.80, 1.09)

0.38

0.14

45

F

AA+AG vs. GG

 

0.88 (0.67, 1.15)

0.34

0.09

55

R

 Children

A vs. G

12

1.45 (1.11,1.89)

0.006

< 0.00001

79

 

AA+AG vs. GG

 

1.43 (1.07, 1.92)

0.02

< 0.00001

78

R

 Adults

A vs. G

10

1.04 (0.83, 1.29)

0.75

0.05

62

R

AA+AG vs. GG

 

1.03 (0.81, 1.32)

0.79

0.004

62

R

Q1 (rs612709)

 G/A

A vs. G

8

1.26 (1.10, 1.45)

0.0007

0.13

37

F

AA vs. GG

 

1.78 (1.11, 2.84)

0.02

0.54

0

F

AG vs. GG

 

1.26 (0.99, 1.60)

0.06

0.04

53

R

AA+AG vs. GG

 

1.27 (1.09, 1.48)

0.002

0.07

47

F

AA vs. AG + GG

 

1.65 (1.04, 2.61)

0.03

0.35

11

F

 Children

A vs. G

3

1.17 (0.95, 1.43)

0.13

0.85

0

F

AA+AG vs. GG

 

1.19 (0.95, 1.50)

0.13

1.00

0

F

S1 (rs3918396)

 G/A

A vs. G

16

0.85 (0.55, 1.31)

0.46

< 0.00001

92

R

AA vs. GG

 

0.39 (0.14, 1.13)

0.08

< 00001

83

R

AG vs. GG

 

0.95 (0.71, 1.27)

0.71

0.0007

62

R

AA+AG vs. GG

 

0.82 (0.54, 1.23)

0.33

< 00001

83

R

AA vs. AG + GG

 

0.60 (0.28, 1.30)

0.20

< 00001

90

R

 Asians

A vs. G

13

0.83 (0.48, 1.43)

0.50

< 0.00001

93

R

AA+AG vs. GG

 

0.76 (0.42, 1.36)

0.35

< 0.00001

84

R

 Caucasians

A vs. G

3

1.05 (0.85, 1.30)

0.66

0.12

54

F

AA+AG vs. GG

 

1.07 (0.85, 1.34)

0.59

0.14

50

F

 Children

A vs. G

4

1.23 (0.96, 1.57)

0.10

0.26

26

F

AA+AG vs. GG

 

1.27 (0.98, 1.66)

0.07

0.35

8

F

S2 (rs528557)

 G/C

C vs. G

29

1.05 (0.86 1.29)

0.63

< 0.00001

92

R

CC vs. GG

 

1.04 (0.70, 1.56)

0.83

< 0.00001

88

R

GC vs. GG

 

1.08 (0.84, 1.38)

0.56

< 0.00001

82

R

CC + GC vs. GG

 

1.06 (0.80, 1.40)

0.70

< 0.00001

88

R

CC vs. GC + GG

 

1.04 (0.82, 1.33)

0.75

< 0.00001

85

R

 Asians

C vs. G

24

1.07 (0.82, 1.41)

0.61

< 0.00001

94

R

CC + GC vs. GG

 

1.09 (0.75, 1.58)

0.66

< 0.00001

89

R

 Caucasians

C vs. G

5

0.96 (0.86, 1.07)

0.45

0.11

47

F

CC + GC vs. GG

 

0.87 (0.63, 1.21)

0.40

0.009

71

R

 Children

C vs. G

9

1.07 (0.70, 1.63)

0.75

< 0.00001

94

R

CC + GC vs. GG

 

1.07 (0.57, 2.01)

0.83

< 0.00001

0

R

 Adults

C vs. G

9

1.04 (0.67, 1.61)

0.87

< 0.00001

96

R

CC + GC vs. GG

 

1.01 (0.59, 1.73)

0.97

< 0.00001

92

R

S + 1 (r2853209)

T vs. A

5

0.91 (0.81, 1.03)

0.14

0.99

0

F

 A/T

TT vs. AA

 

0.82 (0.64, 1.05)

0.12

0.99

0

F

TA vs. AA

 

0.99 (0.81, 1.21)

0.91

0.98

0

F

TT + TA vs. AA

 

0.93 (0.77, 1.13)

0.49

0.99

0

F

TT vs. TA + AA

 

0.82 (0.67, 1.02)

0.07

0.99

0

F

F + 1 (rs511898)

T vs. C

22

1.17 (1.06, 1.30)

0.002

0.0001

61

R

 C/T

TT vs. CC

 

1.43 (1.14, 1.80)

0.002

0.001

55

R

TC vs. CC

 

1.11 (1.01, 1.21)

0.02

0.55

0

F

TT + TC vs. CC

 

1.15 (1.06, 1.26)

0.001

0.11

28

F

TT vs. TC + CC

 

1.29 (1.05, 1.59)

0.02

0.0002

60

R

 Asians

T vs. C

19

1.15 (1.03, 1.28)

0.009

0.003

54

R

TT + TC vs. CC

 

1.13 (1.03, 1.24)

0.01

0.12

28

F

 Children

T vs. C

8

1.26 (1.05, 1.52)

0.01

0.001

71

R

TT + TC vs. CC

 

1.22 (1.07, 1.39)

0.003

0.40

4

F

 Adults

T vs. C

6

1.17 (0.92, 1.48)

0.20

0.0004

76

R

TT + TC vs. CC

 

1.13 (0.83, 1.55)

0.43

0.003

70

R

ST + 4 (rs44707)

 C/A

A vs.C

15

0.90 (0.80, 1.02)

0.09

0.0002

65

R

AA vs. CC

 

0.82 (0.64, 1.04)

0.10

0.0009

62

R

CA vs. CC

 

0.90 (0.81, 1.01)

0.07

0.15

28

F

AA+CA vs. CC

 

0.88 (0.75, 1.03)

0.11

0.01

50

R

AA vs. CA + C

 

0.88 (0.73, 1.05)

0.15

0.004

56

R

 Asians

A vs.C

10

0.92 (0.79, 1.07)

0.28

0.005

62

R

AA+CA vs. CC

 

0.88 (0.72, 1.08)

0.22

0.03

53

R

 Caucasians

A vs.C

4

0.99 (0.87, 1.12)

0.82

0.72

0

F

AA+CA vs. CC

 

1.00 (0.82, 1.22)

0.99

0.56

0

F

 Children

A vs.C

7

0.82 (0.69, 0.97)

0.02

0.04

55

R

AA+CA vs. CC

 

0.81 (0.69, 0.95)

0.010

0.28

19

F

 Adults

A vs.C

4

0.83 (0.66, 1.05)

0.13

0.02

70

R

AA+CA vs. CC

 

0.82 (0.60, 1.12)

0.21

0.05

63

R

V4 (rs2787094)

 C/G

G vs. C

28

1.14 (0.95, 1.36)

0.15

< 0.00001

91

R

GG vs. CC

 

1.25 (0.90, 1.74)

0.18

< 0.00001

85

R

CG vs. CC

 

1.16 (0.97, 1.39)

0.11

< 0.00001

74

R

GG + CG vs. CC

 

1.18 (0.95, 1.47)

0.14

< 0.00001

85

R

GG vs. CG + CC

 

1.17 (0.92, 1.49)

0.20

< 0.00001

84

R

 Asians

G vs. C

22

1.16 (0.92, 1.46)

0.22

< 0.00001

93

R

GG + CG vs. CC

 

1.19(0.88, 1.61)

0.26

< 0.00001

88

R

 Caucasians

G vs. C

6

1.12 (1.00, 1.26)

0.04

0.78

0

F

GG + CG vs. CC

 

1.17 (1.01, 1.36)

0.04

0.94

0

F

 Children

G vs. C

12

0.99 (0.73, 1.36)

0.96

< 0.00001

92

R

GG + CG vs. CC

 

0.98 (0.68, 1.42)

0.92

< 0.00001

85

R

 Adults

G vs. C

7

1.39 (1.04, 1.84)

0.02

< 0.00001

85

R

GG + CG vs. CC

 

1.52 (1.04, 2.21)

0.03

0.0002

77

R

ST + 5 (rs597980)

 C/T

T vs. C

6

1.21 (0.84, 1.73)

0.31

< 0.00001

91

R

TT vs. CC

 

1.41 (0.75, 2.67)

0.29

< 0.00001

88

R

TT + CT vs. CC

 

1.21 (0.83, 1.76)

0.32

0.0001

80

R

TT vs. CT + CC

 

1.30 (0.76, 2.23)

0.34

< 0.00001

89

R

  1. SNPs single nucleotide polymorphisms, N number of included studies, OR odds ratio, 95% CI 95% confidence interval, Ph p-value of heterogeneity, R random-effect model, F fixed-effect model
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