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Table 2 Comparisons between Sarcopenia (lowest quartile of T4MI) (Q4) and the normal group (Q1 + Q2 + Q3) among men and women, respectively

From: Thoracic skeletal muscle quantification: low muscle mass is related with worse prognosis in idiopathic pulmonary fibrosis patients

Variable

Men(n = 143)

Women(n = 37)

Normal (n = 107)

Sarcopenia (n = 36)

P-value

Normal (n = 28)

Sarcopenia (n = 9)

P-value

Age, years

68.1 ± 7.9

70.8 ± 8.9

0.087

70.4 ± 8.2

71.6 ± 13.2

0.808

BMI, kg/m2

24.0 ± 3.1

23.3 ± 3.7

0.283

24.4 ± 3.1

22.7 ± 3.5

0.231

Ever smoker, %

92 (88.8%)

31 (86.1%)

0.336

3 (10.7%)

0 (0.0%)

0.592

Smoking history, pack-years

32.1 ± 23.9

29.7 ± 21.5

0.594

8.3 ± 7.6

0

n/a

Diabetes, n

36 (33.6%)

11 (30.6%)

0.839

8 (28.6%)

4 (44.4%)

0.432

Use of Statins or Sulfonylureas or Glinides, n

42 (39.3%)

11 (30.6%)

0.427

7 (25%)

6 (66.7%)

0.042

FVC, L

2.9 ± 0.7

2.62 ± 0.84

0.096

1.8 ± 0.5

1.7 ± 0.6

0.888

FVC, % predicted

78.9 ± 16.2

72.0 ± 18.9

0.040

73.8 ± 16.3

68.7 ± 18.1

0.516

FEV1, L

2.3 ± 0.6

2.14 ± 0.63

0.241

1.5 ± 0.4

1.5 ± 0.5

0.982

FEV1, % predicted

90.4 ± 18.0

86.1 ± 21.2

0.249

88.9 ± 17.8

85.3 ± 18.4

0.649

FEV1/FVC, %

79.8 ± 9.3

82.6 ± 8.1

0.117

84.6 ± 7.8

87.1 ± 6.6

0.409

DLCO, % predicted

73.7 ± 22.8

64.9 ± 23.9

0.065

59.8 ± 20.3

66.2 ± 22.6

0.551

T4 level muscle CSA, cm2

111.7 ± 17.4

74.7 ± 15.6

< 0.001

78.2 ± 14.8

50.3 ± 8.3

< 0.001

aT4 level muscle index, cm2/m2

40.6 ± 5.8

26.86 ± 5.01

< 0.001

33.0 ± 6.0

20.8 ± 2.0

< 0.001

T12 Erector spinae muscle CSA, cm2

31.8 ± 8.4

21.99 ± 7.46

< 0.001

26.0 ± 5.6

15.2 ± 5.8

< 0.001

bT12 muscle index, cm2/m2

11.6 ± 3.0

7.95 ± 2.85

< 0.001

11.0 ± 2.4

6.2 ± 2.2

< 0.001

Follow-up time, months

38.8 ± 21.0

31.6 ± 23.8

0.087

39.7 ± 21.6

46.2 ± 34.5

0.603

GAP Index score

3.3 ± 1.3

4.0 ± 1.6

0.012

2.7 ± 1.3

3.1 ± 2.1

0.610

1-year survival, number, (%)

96 (89.7%)

28 (77.8%)

0.068

26 (92.9%)

7 (77.8%)

0.205

2-year survival, number, (%)

86 (80.4%)

21 (58.3%)

0.008

25 (89.3%)

6 (66.7%)

0.109

  1. Data are presented as number of patients (%) or mean ± standard deviation
  2. Abbreviations: Q quartile, BMI Body Mass Index, FEV1 Forced Expiratory Volume, FVC Forced Vital Capacity, TLC Total Lung Capacity, DLCO diffusing capacity of carbon monoxide, CSA Cross Sectional Area, GAP gender, age, and physiologic variables
  3. Cutoff values for lower quartile in men and women are 32.53 cm2/m2 and 24.25 cm2/m2, respectively
  4. aT4 level muscle index = CSA of pectoralis, intercostalis, paraspinals, serratus, and latissimus muscles at T4 level/height2
  5. bT12 level muscle index = CSA of erector spinae muscle at T12 level/height2
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Respiratory Research

ISSN: 1465-993X

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