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Table 3 Within-and between-group comparisons of the changes from baseline to endpoint measures for clinical symptoms, basophils, eosinophils and asthma severity in the saffron and placebo groups of asthmatic patients

From: An evaluation of the effects of saffron supplementation on the asthma clinical symptoms and asthma severity in patients with mild and moderate persistent allergic asthma: a double-blind, randomized placebo-controlled trial

Symptoms (frequency per day) Saffron (N = 38) Placebo(N = 38) P-value*
Shortness of breath during the night
 Baseline 0.71 (0.00–1.87) 0.20 (0.00–1.87)  
 8 weeks (endpoint) 0.00 (0.00–1.00) 0.02 (0.00–1.62) < 0.001
 Changes −0.24 (− 1.00–0.00) 0.00 (0.00–0.00)  
P-value¥ < 0.001 0.02  
Waking up due to asthma symptoms
 Baseline 1.00 (0.00–1.00) 0.00 (0.00–1.00)  
 8 weeks (endpoint) 0.00 (0.00–0.00) 0.00 (0.00–1.00) < 0.001
 Changes −0.50 (− 1.00–0.00) 0.00 (0.00–0.00)  
P-value¥ < 0.001 0.02  
Activity Limitation
 Baseline 0.38 (0.14–1.00) 1.00 (0.10–1.87)  
 8 weeks (endpoint) 0.03 (0.000–1.00) 1.00 (0.06–2.00) < 0.001
 Changes −0.14 (−0.79–0.00) 0.00 (0.00–0.00)  
P-value¥ < 0.001 0.49  
Salbutamol spray consumption
Baseline 1.25 (0.02–2.00) 1.00 (0.33–2.00)  
8 weeks (endpoint) 0.14 (0.00–1.00) 1.00 (0.38–2.00) < 0.001
Changes −0.50 (−1.00–0.00) 0.00 (0.00–0.00)  
P-value¥ < 0.001 0.24  
Eosinophil (%)
 Baseline 5.60 (3.00–7.45) 4.90 (3.85–6.50)  
 8 weeks (endpoint) 4.55 (2.82–6.00) 4.90 (2.97–6.00) 0.12
 Changes −0.85 (−1.62) to (0.15) 0.05 (−1.62) to (0.57)  
P-value¥ 0.005 0.58  
Basophil
 Baseline 0.60 (0.3–1.05) 0.60 (0.4–1.20)  
 8 weeks (endpoint) 0.90 (0.50–1.50) 1.10 (0.77–1.50) 0.09
 Changes 0.00 (−0.20) to (0.62) 0.40 (0.00–0.80)  
P-value¥ 0.06 < 0.001  
Asthma severity changes (%)
 Decrease 18.40 2.60  
 No change 78.90 92.10 0.076
 Increase 2.6 5.3  
Asthma severity baseline N(%)
 Mild 14(35) 15 (37.5) 0.81
 Moderate 26 (65) 25 (62.5)
Asthma severity endpoint N(%)
 Mild 20 (52.60) 14 (36.80) 0.16
 Moderate 18 (47.40) 24 (63.20)
  1. *p-value for comparing the changes of variables between the groups. Mann-whitney test was used. ¥p-value for comparing baseline, with endpoint values within each group. Wilcoxon test was used. Values are expressed as median (25th, 75th percentiles) (non-parametric data)