Fig. 5

Pathological alterations in WT mice and NLRP3−/− mice with amplification (200×). Pulmonary pathological changes of WT mice (a-e) and NLRP3−/− mice (f-j) exposed to normal control, vehicle control, LPS, B(a)p or B(a)p plus LPS were evaluated by HE staining. a-e: pathological changes of WT mice in different treatment with amplification (200×); (f-j): pathological changes of NLRP3−/− mice in different treatment with amplification (200×). Blue arrows show inflammatory changes in mice exposed to LPS or vehicles including fractures of alveolar walls, infiltration of inflammatory cells and injury of bronchial epithelium; Red arrows show pathological tumor nests in mice exposed to B(a)p or B(a)p plus LPS