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Table 4 Offspring fed a high fat diet had increased body weights and lengths

From: Maternal high fat diet compromises survival and modulates lung development of offspring, and impairs lung function of dams (female mice)

Outcome

LFD

HFD

First pregnancy

n = 18

n = 8

 Body weight (g)

5.8 ± 0.2

7.4 ± 0.8*

 Body length (snout to vent) (mm)

48.0 ± 0.8

53.5 ± 1.4*

 Body mass index (kg/m2)

2.48 ± 0.06

2.53 ± 0.17*

Second pregnancy

n = 33

n = 7

 Body weight (g)

5.9 ± 0.1

8.9 ± 0.3*†

 Body length (snout to vent) (mm)

49.1 ± 0.6

56.7 ± 1.0*†

 Body mass index (kg/m2)

2.47 ± 0.04

2.77 ± 0.09*§

  1. There was a significant effect of both diet (p < 0.001*) and pregnancy (p < 0.035†) on offspring body weight and length (2-way ANOVA) with no significant interactions (p < 0.299). There was a significant effect of diet only (p < 0.001§) but not pregnancy (p = 0.169) on offspring BMI (2-way ANOVA) with no significant interaction (p = 0.131)
  2. From 4 weeks of age, C57Bl/6 J female mice (n = 28) were separated into 2 treatment groups and fed either a low fat diet (LFD, n = 14) or high fat diet (HFD, n = 14). Female mice were mated with male C57Bl/6 J mice after dams were fed either diet for 12 weeks. Three weeks later, offspring were born. Dams were re-mated 1 week after their first litters were removed at 2 weeks of age. All measures were obtained from offspring at 2 weeks of age. Data are shown as mean ± SEM
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Respiratory Research

ISSN: 1465-993X

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