Fig. 4
The lung volume of offspring and dams was increased by maternal consumption of a high fat diet. From 4 weeks of age, female mice were fed either a low fat diet (LFD, n = 14) or high fat diet (HFD, n = 14). Female mice were mated with male mice, first after dams were fed either diet for 12 weeks, and secondly 1 week after the first litter of offspring was tested for lung function. Offspring of both pregnancies had their lung function measured at 2 weeks of age. The dams had their lung function measured after eating the LFD or HFD for 29 weeks. In (a), thoracic lung volume; (b), specific airway resistance (SRaw); (c), specific tissue damping (SG); (d), specific tissue elastance (SH); and (e), hysteresivity (G/H) measured for offspring born to the first and second matings, and dams (respectively). Data are shown as mean + SEM, with number of mice (n)/treatment shown (*p < 0.05)