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Table 1 Baseline patient characteristics

From: Gasometric gradients between blood obtained from the pulmonary artery wedge and pulmonary artery positions in pulmonary arterial hypertension

Variable

Group 1 pulmonary arterial hypertension

Groups 2–5 pulmonary hypertension

Control group

P (ANOVA / Chi square)

n (%)

65 (50.0)

40 (30.8)

25 (19.2)

 

Age (years)

58 ± 15

59 ± 20

54 ± 20

0.52

Female gender, n (%)

47 (72)

22 (55)

15 (60)

0.17

NYHA functional class, n (%)

 I

5 (8)

4 (10)

6 (24)

0.14

 II

26 (40)

10 (25)

9 (36)

 III

31 (48)

22 (55)

10 (40)

 IV

3 (5)

4 (10)

0 (0)

Supplemental O2, n (%)

29 (45)

21 (53)

6 (24)

0.07

FiO2 in patients on supplemental O2 (%)

42 ± 22

35 ± 16

29 ± 3

0.21

NT-proBNP (pg/mL)

2084 ± 3247

2087 ± 2737

180 ± 153

0.06

6MWD (m)

310 ± 129

317 ± 106

343 ± 130

0.61

DLCOc (% predicted)

54 ± 15

51 ± 28

60 ± 26

0.43

Echocardiography

 TAPSE (cm)

1.90 ± 0.62

1.81 ± 0.62

2.68 ± 0.80

0.45

 RVSP (mm Hg)

73 ± 26

63 ± 22

50 ± 18

0.001

RHC

 RA pressure (mmHg)

8 ± 6

9 ± 5

4 ± 3

0.001

 mPAP (mmHg)

42 ± 14

37 ± 10

17 ± 5

< 0.001

 PAWP (mmHg)

10 ± 5

15 ± 6

8 ± 3

< 0.001

 TPG (mmHg)

32 ± 13

23 ± 10

9 ± 3

< 0.001

 CI (L/min/m2)

3.0 ± 0.9

2.7 ± 0.8

3.2 ± 0.7

0.06

 PVR (Wood units)

6.7 ± 4.2

5.0 ± 3.5

1.5 ± 0.8

< 0.001

Gasometric determinations (PA)

 pH

7.41 ± 0.03

7.39 ± 0.04

7.40 ± 0.03

0.06

 pCO2 (mmHg)

41.8 ± 5.7

47.7 ± 8.5

44.6 ± 4.6

< 0.001

 SO2 (%)

68.1 ± 7.6

66.6 ± 9.7

72.4 ± 5.9

0.02

 COHb (%)

1.6 ± 1.1

1.6 ± 0.9

1.4 ± 1.0

0.68

 metHb (%)

1.0 ± 0.5

0.9 ± 0.4

0.8 ± 0.4

0.22

 Lactic acid (mmoL/L)

0.8 ± 0.4

1.1 ± 0.5

1.0 ± 0.4

0.008

Gasometric determinations (PAW)

 pH

7.54 ± 0.08

7.49 ± 0.10

7.49 ± 0.08

0.02

 pCO2 (mmHg)

27.1 ± 8.2

34.0 ± 10.6

32.3 ± 7.4

0.001

 SO2 (%)

93.6 ± 5.4

92.0 ± 7.0

93.4 ± 3.6

0.38

 COHb (%)

1.8 ± 1.2

1.7 ± 1.1

1.6 ± 1.0

0.88

 metHb (%)

0.8 ± 0.4

0.8 ± 0.4

0.9 ± 0.4

0.84

 Lactic acid (mmoL/L)

0.9 ± 0.4

1.2 ± 0.6

1.1 ± 0.5

0.04

  1. Definition of Abbreviations: COHb: carboxyhemoglobin, CI: cardiac index, DLCOc: diffusion lung capacity for carbon monoxide corrected for hemoglobin, FiO2: fraction of inspired oxygen, metHb: methemoglobin, mPAP: mean pulmonary artery pressure, NT-proBNP: N-terminal pro-B type natriuretic peptide, NYHA: New York Heart Association, PA: pulmonary artery, PAW: pulmonary artery wedge, PAWP: pulmonary artery wedge pressure, pCO2: partial pressure of carbon dioxide, PVR: pulmonary vascular resistance, RA: right atrial, RHC: right heart catheterization, RVSP: right ventricular systolic pressure, SO2:oxygen saturation, TAPSE: tricuspid annular plane systolic excursion, TPG: transpulmonary pressure gradient, 6MWD: distance walked in six-minute walk test
  2. Data are expressed as mean ± SD or n (%)
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Respiratory Research

ISSN: 1465-993X

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