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Table 3 Comparison of patients with echocardiography and patients with missing examination after 12 months

From: Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)

Variable 12 months dropouts [n = 21] 12 months completers [n = 50]  
  Mean ± standard deviation or n and (%) 95% CI (mean) median and interquartile ranges   Mean ± standard deviation or n and % 95% CI (mean) median and interquartile ranges  
N lower limit upper limit N lower limit upper limit p-value
Demographics
 Age [years] 21 59.5 ± 11.66 54.2 64.8 56 [49; 71] 50 59.0 ± 14.2 54.9 63.0 60 [51; 71] 0.845
 Height [cm] 21 170.1 ± 10.95 165.1 175.1 172 [163; 175] 50 166.5 ± 9.3 163.9 169.2 168 [160; 173] 0.267
 Weight [kg] 21 78.7 ± 12.5 73.0 84.4 75.0 [71; 88] 50 76.2 ± 19.3 70.7 81.6 71 [65; 85] 0.196
 BMI [kg/m2] 21 27.2 ± 3.5 25.6 28.8 26.8 [25.7; 28.4] 50 27.3 ± 5.6 25.7 28.9 26.0 [23.3; 30.0] 0.575
 gender [female n (%)]   11 (52.4%)      27 (54.0%)     
Pulmonary hypertension etiology
 Idiopathic PAH   3 (14.3%)      11 (22.0%)     
 Other PAH   6 (28.6%)      12 (24.0%)     
 Chronic thromboembolic pulmonary hypertension   12 (57.1%)      27 (54.0%)     
WHO functional class
 II   6 (28.6%)      11 (22.0%)     
 III   15 (71.4%)      39 (78.0%)     
Pulmonary hypertension targeted treatment
 treatment naÏve   2 (33.3%)      35 (70%)     
 Endothelin-Receptor-Antagonist   2 (33.3%)      12 (24%)     
 Phosphodiesterase-5-inhibitor   2 (33.3%)      3 (6%)     
 Oxygen   2 (33.3%)      5 (10%)     
Vital signs
 Systolic Blood Pressure [mmHg] 21 116 ± 12 110 121 110 [110; 125] 50 114 ± 14 110 121 110 [110; 125] 0.378
 Diastolic Blood Pressure [mmHg] 21 75 ± 10 71 80 76 [70; 80] 50 71 ± 10 68 73 70 [64; 80] 0.040
 Heart Rate [bpm] 21 79 ± 9 75 83 80 [72; 84] 50 81 ± 11 78 84 80 [73; 88] 0.645
Clinical parameters
 NTproBNP [pmol/L] 11 183.7 ± 243.4 20.2 347.2 76 [29.6; 217.4] 30 125.3 ± 228.4 40.0 210.6 42.2 [17.4; 144.8] 0.471
 6-min walking distance [meters] 18 338.5 ± 99.9 288.8 388.2 362 [270; 406] 50 366.4 ± 88.1 341.3 391.4 370 [301; 420] 0.440
Hemodynamics measured by right heart catheter
 mean PAP [mmHg] 13 48.6 ± 54.1 43.0 54.1 47 [45; 57] 32 45.1 ± 10.1 41.5 48.8 43.5 [37.8; 53.3] 0.215
 Pulmonary Vascular Resistance [dyn*sec*cm− 5] 13 781.3 ± 259.3 624.6 938.0 747.8 [615.4; 904.3] 32 668.0 ± 289.3 563.8 772.3 563.1 [495.2; 789.7] 0.112
 Cardiac Index [L/min/m2] 13 2.4 ± 0.5 2.1 2.7 2.5 [2.2; 2.7] 32 2.6 ± 0.5 2.4 2.7 2.6 [2.4; 2.8] 0.276
 Cardiac Output [L/min] 13 4.6 ± 0.9 4.0 5.1 4.6 [4.3; 5.2] 32 4.8 ± 1.1 4.3 5.2 4.6 [4.3; 8.2] 0.861
 Pulmonary Arterial Wedge Pressure [mmHg] 13 6.0 ± 2.7 4.4 7.6 6 [5; 8] 32 7.9 ± 2.8 6.9 8.9 7 [6; 10] 0.052
  1. CI confidence interval, BMI Body mass index, NTproBNP N-terminal fragment of pro brain natriuretic peptide, PAP pulmonary arterial pressure