Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)

Marra, Alberto M.; Halank, Michael; Benjamin, Nicola; Bossone, Eduardo; Cittadini, Antonio; Eichstaedt, Christina A.; Egenlauf, Benjamin; Harutyunova, Satenik; Fischer, Christine; Gall, Henning; Ghofrani, Hossein Ardeschir; Hoeper, Marius M.; Lange, Tobias J.; Olsson, Karen M.; Klose, Hans; Grünig, Ekkehard

doi:10.1186/s12931-018-0957-y

Table 2 Changes of echocardiographic parameters after 3, 6 and 12 months of riociguat treatment

From: Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)

	baseline - 3 months						baseline - 6 months						12 months
		Mean ± standard deviation	95% CI (mean)		median and interquartile ranges			Mean ± standard deviation	95% CI (mean)		median and interquartile ranges			Mean ± standard deviation	95% CI (mean)		median and interquartile ranges
	N	Mean ± standard deviation	lower limit	upper limit	median and interquartile ranges	p-value	N	Mean ± standard deviation	lower limit	upper limit	median and interquartile ranges	p-value	N	Mean ± standard deviation	lower limit	upper limit	median and interquartile ranges	p-value
RA area [cm²]	30	- 1.21 ± 3.94	- 2.67	0.26	1.0 [−4.54; 1.69]	0.104	34	- 2.43 ± 3.74	- 3.73	- 1.13	1.99 [−5.0; 0.29]	< 0.001	49	- 2.58 ± 4.37	- 3.84	- 1.33	2.38 [−6.0; 0.3]	< 0.001
RV area [cm²]	29	-3.0 ± 2.95	−4.12	−1.87	2.0 [−5.0; − 1.0]	< 0.001	32	−3.01 ± 3.15	−4.23	−1.96	−2.36 [−5.5; − 1.0]	< 0.001	44	- 3.51 ± 5.23	−5.1	− 1.92	− 3.25 [− 5.6; 0.0]	< 0.001
TAPSE [mm]	29	0.86 ± 2.97	- 0.27	1.99	0 [−1.0; 2.0]	0.257	32	2.38 ± 4.25	0.85	3.92	2.0 [0; 3.7]	0.003	45	2.95 ± 4.78	1.52	4.39	3.7 [0; 5.5]	< 0.001
FAC [mm]	15	1.67 ± 3.18	−0.09	3.43	0.99 [0; 2.41]	0.068	16	6.13 ± 4.32	3.83	8.43	5.11 [3.69; 8.33]	< 0.001	27	8.12 ± 8.87	4.61	11.62	8.72 [−3.2; 15.0]	< 0.001
RV thickness [mm]	28	−0.68 ± 1.99	−1.45	0.1	0.0 [0.0; 1.75]	0.109	27	−1.13 ± 2.03	−1.94	−0.33	1.0 [0.0; 2.0]	0.008	32	−0.76 ± 2.2	−1.55	0.03	0.9 [0.0; 2.0]	0.023
TRV [cm/sec]	29	- 0.28 ± 0.5	−0.47	−0.09	−0.24 [− 0.4;-0.02]	0.005	32	− 0.48 ± 0.63	−0.71	− 0.25	−0.57 [− 0.71; − 0.07]	< 0.001	47	−0.36 ± 0.83	−0.6	−0.12	− 0.52 [− 0.77; − 0.03]	0.005
IVC diameter [mm]	22	−0.81 ± 3.48	−2.35	0.73	0.5 [−2.0; 0.0]	0.288	25	−0.23 ± 3.83	−1.81	1.35	0.0 [− 2.0; 3.0]	0.764	28	−0.50 ± 4.07	−2.08	1.08	1.0 [−3.45; 2.6]	0.518
LV-EI	27	−0.05 ± 0.17	−0.12	0.02	0.0 [−0.1; 0.0]	0.147	30	−0.005 ± 0.25	−0.1	0.09	0.0 [−0.2; 0.1]	0.906	40	−0.13 ± 0.22	−0.20	−0.06	− 0.1 [− 0.25; 00]	< 0.001
PA diameter [mm]	21	− 0.05 ± 2.09	−1.0	0.9	0.0 [−1.0; 0.0]	0.886	21	−0.99 ± 4.35	−2.97	0.99	0.0 [−2.0; 0.7]	0.309	26	−1.64 ± 3.17	−2.92	0.36	−1.0 [−3.5; 0.0]	0.014

TAPSE tricuspid annular plane systolic excursion, FAC Fractional area change, RA right atrial, RV right ventricular, TRV tricuspid regurgitation velocity, IVC inferior vena cava, LV-EI left ventricular eccentricity index
PA pulmonary artery

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