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Table 2 Changes of echocardiographic parameters after 3, 6 and 12 months of riociguat treatment

From: Right ventricular size and function under riociguat in pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension (the RIVER study)

  baseline - 3 months baseline - 6 months 12 months
  Mean ± standard deviation 95% CI (mean) median and interquartile ranges    Mean ± standard deviation 95% CI (mean) median and interquartile ranges    Mean ± standard deviation 95% CI (mean) median and interquartile ranges  
N lower limit upper limit p-value N lower limit upper limit p-value N lower limit upper limit p-value
RA area [cm2] 30 - 1.21 ± 3.94 - 2.67 0.26 1.0 [−4.54; 1.69] 0.104 34 - 2.43 ± 3.74 - 3.73 - 1.13 1.99 [−5.0; 0.29] < 0.001 49 - 2.58 ± 4.37 - 3.84 - 1.33 2.38 [−6.0; 0.3] < 0.001
RV area [cm2] 29 -3.0 ± 2.95 −4.12 −1.87 2.0 [−5.0; − 1.0] < 0.001 32 −3.01 ± 3.15 −4.23 −1.96 −2.36 [−5.5; − 1.0] < 0.001 44 - 3.51 ± 5.23 −5.1 − 1.92 − 3.25 [− 5.6; 0.0] < 0.001
TAPSE [mm] 29 0.86 ± 2.97 - 0.27 1.99 0 [−1.0; 2.0] 0.257 32 2.38 ± 4.25 0.85 3.92 2.0 [0; 3.7] 0.003 45 2.95 ± 4.78 1.52 4.39 3.7 [0; 5.5] < 0.001
FAC [mm] 15 1.67 ± 3.18 −0.09 3.43 0.99 [0; 2.41] 0.068 16 6.13 ± 4.32 3.83 8.43 5.11 [3.69; 8.33] < 0.001 27 8.12 ± 8.87 4.61 11.62 8.72 [−3.2; 15.0] < 0.001
RV thickness [mm] 28 −0.68 ± 1.99 −1.45 0.1 0.0 [0.0; 1.75] 0.109 27 −1.13 ± 2.03 −1.94 −0.33 1.0 [0.0; 2.0] 0.008 32 −0.76 ± 2.2 −1.55 0.03 0.9 [0.0; 2.0] 0.023
TRV [cm/sec] 29 - 0.28 ± 0.5 −0.47 −0.09 −0.24 [− 0.4;-0.02] 0.005 32 − 0.48 ± 0.63 −0.71 − 0.25 −0.57 [− 0.71; − 0.07] < 0.001 47 −0.36 ± 0.83 −0.6 −0.12 − 0.52 [− 0.77; − 0.03] 0.005
IVC diameter [mm] 22 −0.81 ± 3.48 −2.35 0.73 0.5 [−2.0; 0.0] 0.288 25 −0.23 ± 3.83 −1.81 1.35 0.0 [− 2.0; 3.0] 0.764 28 −0.50 ± 4.07 −2.08 1.08 1.0 [−3.45; 2.6] 0.518
LV-EI 27 −0.05 ± 0.17 −0.12 0.02 0.0 [−0.1; 0.0] 0.147 30 −0.005 ± 0.25 −0.1 0.09 0.0 [−0.2; 0.1] 0.906 40 −0.13 ± 0.22 −0.20 −0.06 − 0.1 [− 0.25; 00] < 0.001
PA diameter [mm] 21 − 0.05 ± 2.09 −1.0 0.9 0.0 [−1.0; 0.0] 0.886 21 −0.99 ± 4.35 −2.97 0.99 0.0 [−2.0; 0.7] 0.309 26 −1.64 ± 3.17 −2.92 0.36 −1.0 [−3.5; 0.0] 0.014
  1. TAPSE tricuspid annular plane systolic excursion, FAC Fractional area change, RA right atrial, RV right ventricular, TRV tricuspid regurgitation velocity, IVC inferior vena cava, LV-EI left ventricular eccentricity index
  2. PA pulmonary artery