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Table 4 Association of admission sex and mineralocorticoid hormone metabolite levels with short- and long-term all-cause mortality in CAP, entire cohort

From: Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study

Entire cohort (N = 285)

All-cause mortality timepoint

30 days

3 years

6 years

HR (95%CI)

p value

HR (95%CI)

p value

HR (95%CI)

p value

Progesterone

 Cox regression analyses

0.72 (95%CI 0.15–3.34)

p = 0.666

0.49 (95%CI 0.28–0.88)

p = 0.016

0.61 (95%CI 0.39–0.97)

p = 0.037

17-OH-Progesterone

 Cox regression analyses

0.73 (95%CI 0.39–1.36)

p = 0.324

0.70 (95%CI 0.52–0.96)

p = 0.027

0.75 (95%CI 0.57–0.98)

p = 0.034

Aldosterone

 Cox regression analyses

1.41 (95%CI 0.56–3.56)

p = 0.461

0.93 (95%CI 0.62–1.37)

p = 0.700

0.81 (95%CI 0.60–1.11)

p = 0.200

DHEA

 Cox regression analyses

45.73 (95%CI 0.01–295,289.2)

p = 0.393

0.46 (95%CI 0.17–1.25)

p = 0.126

0.64 (95%CI 0.36–1.21)

p = 0.119

DHEA-S

 Cox regression analyses

0.57 (95%CI 0.01–25.17)

p = 0.768

0.75 (95%CI 0.50–1.12)

p = 0.155

0.72 (95%CI 0.51–1.01)

p = 0.060

Androstenedione

 Cox regression analyses

2.93 (95%CI 0.74–11.62)

p = 0.126

0.79 (95%CI 0.56–1.12)

p = 0.180

0.90 (95%CI 0.67–1.21)

p = 0.478

Testosterone

 Cox regression analyses

0.80 (95%CI 0.30–2.15)

p = 0.658

1.10 (95%CI 0.71–1.71)

p = 0.656

1.03 (95%CI 0.71–1.51)

p = 0.867

Dihydrotestosterone

 Cox regression analyses

2.45 (95%CI 0.39–15.42)

p = 0.339

1.85 (95%CI 0.93–3.67)

p = 0.078

1.78 (95%CI 1.03–3.09)

p = 0.040

  1. Data for multivariate Cox regression models are presented as HR (95% CI), p value; p values are considered statistically significant at p < 0.05. Bold values indicate statistical significance. All hormone levels were log-transformed and thus the HR corresponds to a 10-fold increase in these levels. CI confidence interval, DHEA dehydroepiandrosterone, DHEA-S dehydroepiandrosterone sulfate, HR hazard ratio
  2. The multivariate model is adjusted for age and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)