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Table 4 Association of admission sex and mineralocorticoid hormone metabolite levels with short- and long-term all-cause mortality in CAP, entire cohort

From: Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study

Entire cohort (N = 285) All-cause mortality timepoint
30 days 3 years 6 years
HR (95%CI) p value HR (95%CI) p value HR (95%CI) p value
Progesterone
 Cox regression analyses 0.72 (95%CI 0.15–3.34) p = 0.666 0.49 (95%CI 0.28–0.88) p = 0.016 0.61 (95%CI 0.39–0.97) p = 0.037
17-OH-Progesterone
 Cox regression analyses 0.73 (95%CI 0.39–1.36) p = 0.324 0.70 (95%CI 0.52–0.96) p = 0.027 0.75 (95%CI 0.57–0.98) p = 0.034
Aldosterone
 Cox regression analyses 1.41 (95%CI 0.56–3.56) p = 0.461 0.93 (95%CI 0.62–1.37) p = 0.700 0.81 (95%CI 0.60–1.11) p = 0.200
DHEA
 Cox regression analyses 45.73 (95%CI 0.01–295,289.2) p = 0.393 0.46 (95%CI 0.17–1.25) p = 0.126 0.64 (95%CI 0.36–1.21) p = 0.119
DHEA-S
 Cox regression analyses 0.57 (95%CI 0.01–25.17) p = 0.768 0.75 (95%CI 0.50–1.12) p = 0.155 0.72 (95%CI 0.51–1.01) p = 0.060
Androstenedione
 Cox regression analyses 2.93 (95%CI 0.74–11.62) p = 0.126 0.79 (95%CI 0.56–1.12) p = 0.180 0.90 (95%CI 0.67–1.21) p = 0.478
Testosterone
 Cox regression analyses 0.80 (95%CI 0.30–2.15) p = 0.658 1.10 (95%CI 0.71–1.71) p = 0.656 1.03 (95%CI 0.71–1.51) p = 0.867
Dihydrotestosterone
 Cox regression analyses 2.45 (95%CI 0.39–15.42) p = 0.339 1.85 (95%CI 0.93–3.67) p = 0.078 1.78 (95%CI 1.03–3.09) p = 0.040
  1. Data for multivariate Cox regression models are presented as HR (95% CI), p value; p values are considered statistically significant at p < 0.05. Bold values indicate statistical significance. All hormone levels were log-transformed and thus the HR corresponds to a 10-fold increase in these levels. CI confidence interval, DHEA dehydroepiandrosterone, DHEA-S dehydroepiandrosterone sulfate, HR hazard ratio
  2. The multivariate model is adjusted for age and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)