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Table 2 Association of admission sex and mineralocorticoid hormone metabolite levels with short- and long-term all-cause mortality in males with CAP

From: Dihydrotestosterone is a predictor for mortality in males with community-acquired pneumonia: results of a 6-year follow-up study

Men (N = 172) All-cause mortality timepoint
30 days 3 years 6 years
  HR (95%CI) p value HR (95%CI) p value HR (95%CI) p value
Progesterone  
Cox regression analyses 0.66 (95%CI 0.11–3.83) p = 0.643 0.66 (95%CI 0.34–1.31) p = 0.239 0.69 (95%CI 0.40–1.18) p = 0.178
17-OH-Progesterone       
Cox regression analyses 0.72 (95%CI 0.35–1.48) p = 0.369 0.66 (95%CI 0.47–0.92) p = 0.015 0.72 (95%CI 0.54–0.97) p = 0.029
Aldosterone       
Cox regression analyses 1.91 (95%CI 0.55–6.63) p = 0.310 1.25 (95%CI 0.74–2.12) p = 0.410 0.89 (95%CI 0.59–1.33) p = 0.565
DHEA       
Cox regression analyses    0.16 (95%CI 0.01–3.79) p = 0.255 0.67 (95%CI 0.35–1.27) p = 0.221
DHEA-S       
Cox regression analyses 0.57 (95%CI 0.01–25.17) p = 0.768 0.69 (95%CI 0.20–2.42) p = 0.562 0.55 (95%CI 0.18–1.67) p = 0.293
Androstenedione       
Cox regression analyses 5.46 (95%CI 0.85–35.12) p = 0.074 0.59 (95%CI 0.34–0.99) p = 0.049 0.65 (95%CI 0.40–1.05) p = 0.081
Testosterone       
Cox regression analyses 0.69 (95%CI 0.16–2.94) p = 0.613 1.36 (95%CI 0.73–2.52) p = 0.328 1.04 (95%CI 0.64–1.72) p = 0.865
Dihydrotestosterone       
Cox regression analyses 6.08 (95%CI 0.15–254.59) p = 0.344 2.0 (95%CI 0.64–6.27) p = 0.236 2.84 (95%CI 1.15–6.99) p = 0.023
  1. Data for multivariate Cox regression models are presented as HR (95% CI), p value; p values are considered statistically significant at p < 0.05. Bold values indicate statistical significance. All hormone metabolite levels were log-transformed and thus the HR corresponds to a 10-fold increase in these levels. CI confidence interval, DHEA dehydroepiandrosterone, DHEA-S dehydroepiandrosterone sulfate, HR hazard ratio
  2. The multivariate model is adjusted for age and comorbidities (coronary artery disease, cerebrovascular disease, chronic kidney disease, neoplastic disease)