Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

Respiratory Research

Table 3 Plasma Mediators of the Association between Chronic Obstructive Pulmonary Disease and Coronary Artery Calcification

Mediator^a	Indirect Effect	Bootstrap Bias Corrected 95% CI for Indirect Effect	Direct Effect	% Effect Mediated	Sobel p-value
A. Airflow obstruction (FEV₁/FVC) and CAC
MMP3 (ng/mL)	−0.061	−0.126 to − 0.022	−0.662	8.5	0.015
VCAM1 (ng/mL)	−0.057	−0.134 to − 0.020	−0.666	7.9	0.019
CXCL9 (pg/mL)	−0.114	−0.194 to − 0.057	−0.609	15.8	< 0.001
CXCL5 (ng/mL)	−0.049	−0.102 to − 0.015	−0.673	6.8	0.040
B. Centrilobular Emphysema and CAC
MMP3 (ng/mL)	0.019	0.006 to 0.042	0.226	7.9	0.033
VCAM1 (ng/mL)	0.018	0.004 to 0.041	0.227	7.3	0.041
CXCL9 (pg/mL)	0.042	0.022 to 0.074	0.203	17.0	0.001

CAC Coronary artery calcification, FEV₁ Forced expiratory volume in the first second, FVC Forced vital capacity, MMP3 Matrix metalloproteinase 3. VCAM1 = Vascular cell adhesion molecule 1. CXCL = C-X-C Motif Chemokine Ligand
^aAll mediators were log transformed prior to analysis

ISSN: 1465-993X