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Table 3 Plasma Mediators of the Association between Chronic Obstructive Pulmonary Disease and Coronary Artery Calcification

From: Centrilobular emphysema and coronary artery calcification: mediation analysis in the SPIROMICS cohort

Mediatora Indirect Effect Bootstrap Bias Corrected 95% CI for Indirect Effect Direct Effect % Effect Mediated Sobel p-value
A. Airflow obstruction (FEV1/FVC) and CAC
 MMP3 (ng/mL) −0.061 −0.126 to − 0.022 −0.662 8.5 0.015
 VCAM1 (ng/mL) −0.057 −0.134 to − 0.020 −0.666 7.9 0.019
 CXCL9 (pg/mL) −0.114 −0.194 to − 0.057 −0.609 15.8 < 0.001
 CXCL5 (ng/mL) −0.049 −0.102 to − 0.015 −0.673 6.8 0.040
B. Centrilobular Emphysema and CAC
 MMP3 (ng/mL) 0.019 0.006 to 0.042 0.226 7.9 0.033
 VCAM1 (ng/mL) 0.018 0.004 to 0.041 0.227 7.3 0.041
 CXCL9 (pg/mL) 0.042 0.022 to 0.074 0.203 17.0 0.001
  1. CAC Coronary artery calcification, FEV1 Forced expiratory volume in the first second, FVC Forced vital capacity, MMP3 Matrix metalloproteinase 3. VCAM1 = Vascular cell adhesion molecule 1. CXCL = C-X-C Motif Chemokine Ligand
  2. aAll mediators were log transformed prior to analysis