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Fig. 2 | Respiratory Research

Fig. 2

From: Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling

Fig. 2

Weight loss and right ventricular systolic pressure (RVSP) measurements in mice treated with silica. Deficiency of SOD3 increased body weight loss in early stage of silica-induced lung fibrosis. a Effect of SOD3 gene knockout on body weight loss after intratracheal injection of crystalline silica. Body weight was measured for 28 days. *p < 0.05 for silica-challenged Sod3−/− versus silica-challenged Sod3+/+ mice. b Histochemical analysis of silicotic nodules in the lung of Sod3+/+ and Sod3−/− mice treated with crystalline silica. 40x magnification. c Analysis of collagen specific blue staining. t-test, * < 0.05. d Collagen accumulation in the lung. The results are shown as mean ± SEM, *p < 0.05 when compared to control lung, One Way ANOVA with Holm-Sidak post test

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