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Table 2 Cut-off values and diagnostic accuracy measures of AGEs, sRAGE and AGEs/sRAGE ratio

From: Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis

  IPF – fNSIP cHP – fNSIP
Indicators AGE sRAGE Ratio AGE sRAGE Ratio
Cut-off value 19.25 μg/ml 782.59 pg/ml 25.65 ‰ 20.92 μg/ml 529.57 pg/ml 24.87 ‰
Sensitivity (%) 69.77 89.66 100.00 73.33 85.71 75.00
Specificity (%) 85.00 64.71 94.12 95.00 82.35 88.24
Accuracy (%) 74.60 84.00 98.28 85.71 83.87 81.82
LR+ 4.65 2.54 17.00 14.67 4.86 6.38
J 0.55 0.54 0.94 0.68 0.68 0.63
  1. AGE advanced glycation end-product, cHP chronic hypersensitivity pneumonitis, fNSIP fibrotic non-specific interstitial pneumonia, J Youden’s index, LR+ Likelihood ratio for positive test results, IPF idiopathic pulmonary fibrosis, sRAGE soluble receptor for advanced glycation end-products