Fig. 1
From: Therapeutic potential of products derived from mesenchymal stem/stromal cells in pulmonary disease
Extracellular vesicles secreted by mesenchymal stem cells transfer their cargo to the recipient cells. In culture mesenchymal stem cells secrete exosomes and microvesicles that can transfer variety of bioactive factors to the recipient cells via ligand-receptor interaction, direct membrane fusion, endocytosis, or phagocytosis. Ang1—angiopoietin 1, CXCR7 – chemokine (C-X-C motif) receptor 7, EGFr – epidermal growth factor receptor, IL-8 – interleukin 8, IL-1ra – IL-1 receptor antagonist, KGF – keratinocyte growth factor, mRNA – messenger RNA, miRNA – micro RNA, PS – phosphatidylserine, TGF-β – transforming growth factor beta, VEGF – vascular endothelial growth factor