Association of lung function with cardiovascular risk: a cohort study

Respiratory Research

Table 3 Odds ratios for 10-Year CVD Risk according to lung function parameters (N = 4019)

Variables	ORs (95% CI) by Continuous lung function^a	ORs (95% CI) by groups of lung function parameters				p _trend
FEV₁/FVC (%)		L4 (≥90)	L3 (80 ~ < 90)	L2 (70 ~ < 80)	L1 (< 70)
N (≥10% / < 10%)	1567/2452	556/1050	631/1033	319/329	61/40
Adjusted OR (95% CI)	1.12 (1.07, 1.17)	1.00 (ref.)	1.11 (0.94, 1.31)	1.63 (1.31, 2.03)	2.37 (1.43, 3.91)	< 0.001
FVC (L)		Q4 (> 2.9)	Q3 (2.5~ 2.9)	Q2 (2.1~ 2.4)	Q1 (≤2.0)
N (≥10% / < 10%)	1567/2452	358/526	347/683	343/715	519/528
Adjusted OR (95% CI)	1.07 (1.06, 1.08)	1.00 (ref.)	2.34 (1.79, 3.06)	4.33 (3.18, 5.90)	9.82 (7.11, 13.56)	< 0.001
FEV₁ (L)		Q4 (> 2.5)	Q3 (2.2~ 2.5)	Q2 (1.9~ 2.1)	Q1 (≤1.8)
N (≥10% / < 10%)	1567/2452	363/554	311/690	284/608	609/600
Adjusted OR (95% CI)	1.09 (1.08, 1.10)	1.00 (ref.)	2.33 (1.77, 3.07)	4.10 (3.00, 5.60)	10.37 (7.58, 14.19)	< 0.001

Abbreviations: FEV₁ forced expiratory volume in 1 s, FVC forced vital capacity, FEV₁/FVC the ratio of FEV₁ to FVC OR odds ratio; CI confidence interval
Adjusted for gender (male/female), height (continuous, m), weight (continuous, kg), abdominal obesity (yes/no), smoking amount (continuous, pack-year), drinking status (drinker/nondrinker), low density lipoprotein (continuous, mmol/L), physical activity (active/inactive), city (Wuhan/Zhuhai) and education levels (middle school or below, high school, university or above)
^aOdds ratios were estimated by each 5% decrease of FEV₁/FVC or each 50-mL decrease of FVC or FEV₁ in continuous analyses

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