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Fig. 4 | Respiratory Research

Fig. 4

From: Upregulation of microRNA-17-5p contributes to hypoxia-induced proliferation in human pulmonary artery smooth muscle cells through modulation of p21 and PTEN

Fig. 4

miR-17-5p regulates the expression of proteins involved in cell cycle progression, cell proliferation and apoptosis in PASMCs in vitro. PASMCs were transfected with miR-17-5p agomir (miR-17-5p) or miR-17-5p antagomir (anti-miR-17-5p) oligonucleotides. mRNA levels of four target genes of miR-17-5p (a). The expression levels of two target genes of miR-17-5p were determined by western blot (b‑d). mRNA levels of five genes involved in cell cycle progression, cell proliferation and apoptosis in PASMCs (f). The results are expressed as the means ±SD of at least three independent experiments, and qRT-PCR was conducted in triplicate. *P < 0.05, #P < 0.01

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Respiratory Research

ISSN: 1465-993X

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