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Fig. 8 | Respiratory Research

Fig. 8

From: Antiestrogen- and tamoxifen-induced effects on calcium-activated chloride currents in epithelial cells carrying the ∆F508-CFTR point mutation

Fig. 8

Synergic action of VXs/FSK and TMX/ATP on increasing membrane chloride current in CFBE cells. a example of the current/voltage relationship showing current density data from CBE cells after incubation with VXs/FSK (squares) and subsequent addition of TMX/ATP (circles) compared with control condition (triangles). b the histogram with the single experiments (grey diamonds) compares current density at + 80 mV membrane potential for CFBE cells stimulated with VXs/FSK (n = 4), TMX/ATP (n = 7) or the combination of both compounds (n = 4). The ion channel blockers Inh-172 and NPPB drastically reduced the membrane current (n = 3). The values of the light gray column on the right of the histogram were obtained by mathematical addition of the average current densities of cells stimulated separately with VXs/FSK and TMX/ATP

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Respiratory Research

ISSN: 1465-993X

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