Fig. 5

PrtA immunization failed to protect mice against acute pneumococcal pneumonia. S. pneumoniae D39 was intranasally administered to immunized group and the adjuvant control group. a Bacterial load in the lungs and (b) subsequent bloodstream invasion were examined 1, 2, and 3 days post infection. The open circle represents the curdlan-treated mice, and the filled circle represents the PrtA1/curdlan-immunized mice. The data were pooled from one or two experiments. At least three mice per experiment were used