Cluster 1 | Cluster 2 | Cluster 3 | Cluster 4 | P value | |
---|---|---|---|---|---|
N = 92 | N = 45 | N = 87 | N = 55 | ||
Blood/serum biomarkers | |||||
RBC distribution width (%) | 14.25 (1.17) | 14.04 (0.87) | 13.63 (0.84) | 14.13 (1.19) | 0.0016 |
Total WBC count (N/μl) | 7153.15 (2290.62) | 7352.89 (2527.31) | 7109.77 (1954.51) | 7073.09 (2122.85) | 0.924 |
Neutrophils% (%) | 58.06 (9.52) | 58.24 (11.78) | 58.06 (9.65) | 61.14 (10.22) | 0.26 |
Lymphocyte% (%) | 31.35 (8.09) | 31.39 (10.45) | 30.81 (8.58) | 27.74 (9.53) | 0.088 |
Monocyte% (%) | 7.3 (2.5) | 7.46 (2.12) | 7.67 (2.18) | 7.85 (2.2) | 0.512 |
Eosinophils% (%) | 2.63 (1.64) | 2.29 (1.74) | 2.72 (1.75) | 2.61 (1.9) | 0.6 |
Basophils% (%) | 0.71 (0.61) | 0.52 (0.36) | 0.62 (0.54) | 0.68 (0.64) | 0.278 |
Baseline CAT scorea | |||||
13.17 (7.95) | 16.45 (9.54) | 13.78 (7.86) | 20.06 (7.86) | < 0.0001 | |
Exacerbations | |||||
Severeb | 0.2 (0.6) | 0.44 (1.62) | 0.31 (0.82) | 1.25 (2.27) | < 0.0001 |
Totalc | 0.49 (1.19) | 1.09 (3.39) | 0.92 (2.14) | 2.09 (2.91) | < 0.0001 |
Total at baselined | 0.25 (0.68) | 0.58 (1.39) | 0.22 (0.63) | 0.62 (0.99) | 0.011 |
Activity limitation | |||||
6-min walk distance (m) | 445.66 (91.31) | 386.64 (136.27) | 420.38 (71.19) | 385.16 (94.09) | 0.0003 |
Oxygen desaturation with 6-min walk (%) | 14 | 36 | 14 | 41 | < 0.0001 |