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Table 1 Characteristics of patients with pneumonia and healthy subjects

From: Dual effects of human neutrophil peptides in a mouse model of pneumonia and ventilator-induced lung injury

 

Pneumonia (N = 43)

Healthy (N = 43)

Age (year)

63.8 ± 2.4

63.3 ± 0.7

Female/Male

12/31

19/24

APACHE II

18.1 ± 1.0

 

MV mode

 IPPV

44% (N = 19)

 

 SIMV

26% (N = 11)

 

 A/C

14% (N = 6)

 

 Others

16% (N = 7)

 

VT (mL)

425.9 ± 6.9

 

PEEP (cmH2O)

6.9 ± 0.5

 

PaO2/FiO2

168.4 ± 10.3

 

WBC counts (× 109/L)

14.3 ± 1.2*

7.9 ± 0.3

Neutrophil counts (×109/L)

12.8 ± 1.1*

6.1 ± 0.3

Hemoglobin (g/L)

94.9 ± 2.8*

142.5 ± 1.8

PLT counts (×109/L)

209.6 ± 25.4*

253.9 ± 6.8

Creatinine (μmol/L)

113.8 ± 15.0

 

PCT (μg/L)

17.0 ± 6.8

 

HSCPR (mg/L)

62.0 ± 13.8

 

HNP concentration (ng/mL)

215.9 ± 39.1*

27.6 ± 2.0

Etiology of pneumonia

 Acinetobacter baumannii

35% (N = 15)

 

 Pseudomonas aeruginosa

14% (N = 6)

 

 Stenotrophomonas maltophilia

9% (N = 4)

 

 Staphylococcus haemolyticus

7% (N = 3)

 

 Klebsiella pneumoniae

7% (N = 3)

 

 Staphylococcus aureus

7% (N = 3)

 

 Others

21% (N = 9)

 

Co-morbidities

 COPD

23% (N = 10)

 

 Hypertension

35% (N = 15)

 

 Diabetes

19% (N = 8)

 

 Renal failure

14% (N = 6)

 

 Asthma

2% (N = 1)

 

Corticosteroid treatment

37% (N = 16)

 

ICU stay (days)

28.9 ± 3.5

 

ICU mortality (%)

33%

 
  1. Note: Data shown are mean ± SEM. * p < 0.01 vs. Healthy
  2. Abbreviations: A/C assist/control, APACHE acute physiology and chronic health evaluation, COPD chronic obstructive pulmonary disease, HNP human neutrophil peptides, HSCPR high-sensitivity C-reactive protein, ICU intensive care unit, IPPV intermittent positive pressure ventilation, MV mechanical ventilation, PCT procalcitonin, PEEP positive end expiratory pressure, PLT platelet, SIMV synchronized intermittent mandatory ventilation, VT tidal volume, WBC white blood cell