Fig. 6
Effects of MRS2578 on histological changes after two-hit lung injury. Mice were intranasally instilled with P. aeruginosa (1× 106 CFU) or PBS and received MRS2578 or vehicle (DMSO) 15 min, 24 h and 48 h after pneumonia, and then subjected to mechanical ventilation with either low (LP) or high (HP) pressure for 2 h. Lung histology (H&E) was obtained 72 h h after pneumonia. Pulmonary edema (black arrow) and neutrophil infiltration (circle) were indicated