Fig. 3
From: IL-32γ attenuates airway fibrosis by modulating the integrin-FAK signaling pathway in fibroblasts
Anti-fibrotic effects of rIL-32γ are independent of TNF-α. a Fibronectin and α-SMA expression in MRC-5 cells after 24 h of stimulation with TNF-α (10 ng/mL) and TGF-β (5 ng/mL). b MRC-5 cells were transfected with IL-32 siRNA and then stimulated with TNF-α (10 ng/mL) or TGF-β (5 ng/mL). c Fibronectin and α-SMA expression in cell lysates was detected. d Infliximab-pretreated MRC-5 cells were stimulated with IL-32γ (150 ng/mL) and TGF-β (5 ng/mL), and fibronectin and α-SMA expression in the cell lysate was detected. Results are representative of two independent experiments, each showing similar results