| With rPPFE | Without rPPFE | P |
---|---|---|---|
Number | 30 | 88 | |
Demographics | |||
 Age | 45.5 (37, 51) | 51 (43, 56) | 0.05 |
 Male | 13 (43.3) | 58 (65.9) | 0.03 |
 Ever-smoking | 8 (26.7) | 54 (61.4) | 0.001 |
 Previous pneumothorax | 24 (80.0) | 23 (26.1) | < 0.001 |
 Family history | 2 (6.7) | 21 (23.9) | 0.16 |
 mMRC [1] | 3 (3, 4) | 4 (3, 4) | 0.15 |
 BMI | 15.9 (14.8, 17.2) | 21.5 (18.8, 25.1) | < 0.001 |
Serum biomarkers | |||
 KL-6, IU/L | 542 (402, 698) | 1460 (933, 2150) | < 0.001 |
 LDH, IU/L | 186.5 (172, 212) | 229 (202, 271) | < 0.001 |
Pulmonary function tests | |||
 %FVC | 35.75 (22.6, 46.2) | 48.5 (37.6, 62.0) | < 0.001 |
 %DLCO | 45.5 (37, 51) | 24.4 (17.4, 31.9) | 0.002 |
Six-minute walk test | |||
 Distance, meter | 375 (243, 500) | 333 (235, 454) | 0.36 |
 Distance < 250 m | 8 (26.7) | 26 (29.5) | 0.82 |
 Lowest SpO2, % | 87.5 (81, 93) | 81 (76, 87) | < 0.001 |
Arterial blood gas analysis | |||
 PaO2, Torr | 77.8 (65.4, 86.6) | 74.05 (63.4, 87.9) | 0.73 |
 PaCO2, Torr | 49.55 (45.6, 56.9) | 43.55 (40.7, 47.55) | < 0.001 |
Treatment | |||
 Corticosteroid | 11 (36.7) | 62 (70.5) | 0.002 |
 IS agent | 3(10.0) | 40 (45.5) | < 0.001 |
 Antifibrotic agent | 7 (23.3) | 39 (44.3) | 0.05 |
 LTOT | 15 (50.0) | 63 (71.6) | 0.04 |