SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

Table 5 Association of previously reported COPD associated cg02181506 and cg2462102

Circulating AAT^a	cg02181506		cg24621042
	Coef.	P _value	Coef.	P _value
	− 0.78	0.08	− 0.68	0.04
Adults (SAPALDIA, NFBC66, ECRHS)
FEV₁, repeat cross-sectional	0.28	0.47	−0.15	0.60
FEV₁, change	0.02	0.71	−0.01	0.87
Children and Adolescents (ALSPAC)
FEV₁, repeat cross-sectional	1.42	0.35	0.31	0.29
FEV₁, change	−0.54	0.26	− 0.17	0.06
Adults (SAPALDIA, NFBC66, ECRHS)
FEV₁/FVC, repeat cross-sectional	−0.03	0.58	0.07	0.09
FEV₁/FVC, change	0.00	0.80	−0.01	0.09
Children and Adolescents (ALSPAC)
FEV₁/FVC, repeat cross-sectional	0.01	0.98	0.08	0.07
FEV₁/FVC, change	−0.12	0.06	0.00	0.71

Direction of effect for SAPALDIA, ECRHS and NFBC: a positive sign indicates that an increase in methylation is associated with higher level of lung function (cross-sectional models) and with an attenuation of lung function decline in the prediction models (change in lung function). In ALSPAC children, a positive sign indicates that an increase in methylation is associated with higher level of lung function (cross-sectional models) and with lung function growth in the prediction models (change in lung function)
Association of Previously Reported COPD Associated cg02181506 and cg2462102 with Circulating AAT and Lung Function in Adults, Children and Adolescents
^a SAPALDIA cohort, first time point

ISSN: 1465-993X