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Table 4 Characteristics of tobacco-smoke exposed children and adolescentsa, ALSPAC

From: SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults: a meta-analysis of ALEC population-based cohorts

  Children Cross-Sectional T1 (2000) Adolescents Cross-Sectional T2 (2007)
N 259 259
Females (%) 53.7 53.7
Age (years), mean (SDb) 8.6 (0.2) 15.4 (0.3)
Height (cm), mean (SD) 133.3 (6.0) 170.2 (8.0)
Weight (kg), mean (SD) 31.3 (6.3) 62.8 (11.0)
BMI 17.4 (2.5) 21.7 (3.3)
Maternal Education (%)
 Ordinary Level or Lower 56.4 56.4
 Advanced Level 27.8 27.8
 University 15.8 15.8
Asthmatics (%) 21.6 28.9
Smoking Exposure (%)
 In-utero smoking (smoking mother) 25.1 25.1
 Second-hand exposure at home 56.0 56.0
 Self-exposure (smoked > 2 times in a life-time) 52.1 52.1
COPD [FEV1/FVC < LLNc] (%) 5.0 4.6
Asthma medications in the last 12 months (%) 14.0 14.0
FVC(L), mean (SD) 2.0 (0.3) 3.9 (0.9)
FEV1(L), mean (SD) 1.7 (0.3) 3.4 (0.7)
FEV1/FVC(L), mean (SD) 0.9 (0.06) 0.9 (0.07)
  1. aChildren and adolescents exposed to tobacco-smoke defined as: mother smoked during pregnancy and/or lived with a smoker and/or reported smoking ≥ twice in their lifetime
  2. bSD, standard deviation
  3. cLLN, lower limit of normal estimated using GLI2012 reference equations