Skip to main content

Table 1 Characteristics of studies included into the meta-analysis

From: Augmented expression of Ki-67 is correlated with clinicopathological characteristics and prognosis for lung cancer patients: an up-dated systematic review and meta-analysis with 108 studies and 14,732 patients

Study(author/year) Region Tumor stage Histological type Patients Sample size Cutoff value Sample type Assay NOS score Extract method Survival
Scagliotti 1993 [91] Italy I-IIIA NSCLC 111 Large 25% Tumor tissue IHC 7 Survival curve OS
Pence 1993 [120] USA I-IV NSCLC 61 Small 4% Tumor tissue IHC 7 Survival curve OS
Fontanini 1996 [46] Italy NA NSCLC 70 Small 30% Tumor tissue IHC 7 Survival curve OS
Bohm 1996 [37] Germany NA SCLC 32 Small 27% Tumor tissue IHC 7 Original data OS
Harpole 1996 [50] USA I NSCLC 275 Large 7% Tumor tissue IHC 9 Multivariate OS
Pujoll 1996 [88] France I-IV LC 97 Small NA Tumor tissue IHC 7 Survival curve OS
Mehdi 1999 [119] USA I-IV NSCLC 203 Large 25% Tumor tissue IHC 9 Multivariate OS and DFS
Demarchi 1999 [41] Brazil I-III ADC 64 Small 22% Tumor tissue IHC 7 Original data OS
Dingemans 1999 [42] Netherland I-III SCLC 93 Small 30% Tumor tissue IHC 7 Survival curve OS
Wang 1999 [99] China NA NSCLC 85 Small 30% Tumor tissue IHC 7 Survival curve OS
Shiba 2000 [92] Japan I-III NSCLC 95 Small 20% Tumor tissue IHC 7 Univariate OS
Hommura 2000 [54] Japan I-II SQC 91 Small 30% Tumor tissue IHC 9 Multivariate OS
Hommura 2000 [54] Japan I-II NSCLC 124 Large 30% Tumor tissue IHC 9 Multivariate OS
Nguyen 2000 [80] Czech Republic I-IV NSCLC 89 Small 30% Tumor tissue IHC 7 Survival curve OS
Puglisi 2001 [87] Italy I-III NSCLC 81 Small 30% Tumor tissue IHC 9 Multivariate OS
Hayashi 2001 [52] Japan I-IV NSCLC 98 Small 13% Tumor tissue IHC 9 Multivariate OS
Pelosi 2001 [84] Italy I SQC 119 Large NA Tumor tissue IHC 9 Multivariate OS and DFS
Ramnath 2001 [121] USA I-IV NSCLC 160 Large 24% Tumor tissue IHC 7 Univariate OS
Ramnath 2001 [121] USA I-IV NSCLC 41 Small 50% Tumor tissue IHC 7 Univariate OS
Wang 2001 [101] China I-IV LC 166 Large 18% Tumor tissue IHC 7 Survival curve OS
Mojtahedzadeh 2002 [78] Japan I-III ADC 141 Large 10% Tumor tissue IHC 8 Multivariate OS
Minami 2002 [76] Japan I ADC 47 Small 20% Tumor tissue IHC 8 Multivariate OS
Takahashi 2002 [94] Japan I-IV NSCLC 62 Small 25% Tumor tissue IHC 9 Multivariate DFS
Wakabayashi 2003 [97] Japan I-IV NSCLC 140 Large 13% Tumor tissue IHC 9 Multivariate OS
Pelosi 2003 [85] UK I ADC 96 Small NA Tumor tissue IHC 9 Multivariate OS
Haga 2003 [49] Japan I ADC 58 Small 10% Tumor tissue IHC 9 Multivariate OS
Hashimoto 2003 [51] Japan I-III ADC 122 Large 20% Tumor tissue IHC 8 Multivariate OS
Poleri 2003 [86] Argentina I NSCLC 50 Small 67% Tumor tissue IHC 7 Survival curve DFS
Matheus 2004 [75] Brazil I-III ADC 33 Small 22% Tumor tissue IHC 7 Original data OS
Niemiec 2004 [81] Poland I-III SQC 78 Small 28% Tumor tissue IHC 7 Survival curve OS
Ahn 2004 [33] Korea II-IIIA NSCLC 65 Small 15% Tumor tissue IHC 9 Multivariate OS
Huang 2005 [55] Japan I NSCLC 97 Small 25% Tumor tissue IHC 8 Multivariate OS
Gasinska 2005 [48] Poland I-III SQC 81 Small 39% Tumor tissue IHC 9 Multivariate OS
Wang 2005 [100] China I-III NSCLC 51 Small 5% Tumor tissue IHC 7 Survival curve OS
Dong 2005 [43] Japan I-IV ADC 131 Large 18% Tumor tissue IHC 9 Multivariate OS
Niemiec 2005 [81] Poland I-III SQC 78 Large 28% Tumor tissue IHC 7 Survival curve OS
Huang 2005 [55] Japan II-III NSCLC 76 Small 25% Tumor tissue IHC 8 Multivariate OS
Tsubochi 2006 [64] Japan I-III NSCLC 219 Large 20% Tumor tissue IHC 9 Multivariate OS
Yang 2006 [110] USA I-III NSCLC 128 Large 25% Tumor tissue IHC 9 Multivariate OS
Nozawa 2006 [82] Japan IV ADC 35 Small 40% Tumor tissue IHC 7 Survival curve OS
Maddau 2006 [118] Italy II-III NSCLC 88 Large 25% Tumor tissue IHC 7 Univariate OS
Maddau 2006 [118] Italy I NSCLC 92 Large 25% Tumor tissue IHC 7 Univariate OS
Inoue 2007 [58] Japan I-III ADC 97 Small 5% Tumor tissue IHC 9 Multivariate DFS
Mohamed 2007 [77] Japan I-IV NSCLC 61 Small 20% Tumor tissue IHC 9 Multivariate OS
Zhou 2007 [116] China I-II NSCLC 70 Small NA Tumor tissue IHC 6 Multivariate OS
Morero 2007 [79] Argentina III NSCLC 32 Small 66% Tumor tissue IHC 7 Survival curve OS
Yoo 2007 [112] Korea I-III NSCLC 219 Large 30% Tumor tissue IHC 9 Multivariate OS
Fujioka 2008 [47] Japan I ADC 73 Small 14% Tumor tissue IHC 9 Multivariate OS
Imai 2008 [57] Japan I NSCLC 248 Large 25% Tumor tissue IHC 9 Multivariate OS
Woo 2008 [103] Japan Ia ADC 131 Large 10% Tumor tissue IHC 8 Univariate DFS
Woo 2008 [103] Japan Ib ADC 59 Small 10% Tumor tissue IHC 8 Univariate DFS
Saad 2008 [89] USA I-III NSCLC 54 Small 30% Tumor tissue IHC 7 Survival curve OS
Kaira 2008 [124] Japan I-III NSCLC 321 Large 25% Tumor tissue IHC 9 Multivariate OS
Ikeda 2008 [56] Japan I-III NSCLC 200 Large 5% Tumor tissue IHC 7 Univariate OS and DFS
Anami 2009 [34] Japan I-IV ADC 139 Large 10% Tumor tissue IHC 8 Multivariate OS
Yuan 2009 [113] China I-III NSCLC 140 Large 25% Tumor tissue IHC 8 Multivariate OS
Kaira 2009 [62] Japan 1 ADC 139 Large 20% Tumor tissue IHC 9 Multivariate OS
Erler 2010 [44] USA NA SCLC 68 Small 50% Tumor tissue IHC 7 Survival curve OS
Filipits 2011 [45] Austria I-III NSCLC 778 Large NA Tumor tissue IHC 9 Multivariate OS and DFS
Werynska 2011 [102] Poland I-IV NSCLC 145 Large 25% Tumor tissue IHC 7 Univariate OS
Yamashita 2011 [109] Japan I NSCLC 44 Small 5% Tumor tissue IHC 8 Multivariate DFS
Wu 2011 [106] China I-IV NSCLC 160 Large 10% Tumor tissue IHC 8 Multivariate OS
Oka 2011 [83] Japan I-III ADC 183 Large 20% Tumor tissue IHC 9 Multivariate DFS
Sterlacci 2011 [122] Austria I-IV NSCLC 386 Large 3% Tumor tissue IHC 9 Multivariate OS
Werynska 2011 [102] Poland NA NSCLC 145 Large 25% Tumor tissue IHC 7 Univariate OS
Liu 2012 [71] China I-IV NSCLC 494 Large 50% Tumor tissue IHC 9 Multivariate OS
Wang 2012 [98] China NA SCLC 42 Small 10% Tumor tissue IHC 7 Survival curve OS
Liu 2012 [71] China I-IV ADC 97 Small 10% Tumor tissue IHC 7 Survival curve OS
Wu 2012 [105] China I-IV ADC 309 Large 50% Tumor tissue IHC 9 Multivariate OS
Salvi 2012 [90] Italy I-III NSCLC 81 Small 15% Tumor tissue IHC 9 Multivariate OS
Yang 2012 [111] China I-III NSCLC 68 Small 38% Tumor tissue IHC 7 Survival curve OS
Wu 2013 [104] China I-IV NSCLC 192 Large 10% Tumor tissue IHC 9 Multivariate OS and DFS
Maki 2013 [74] Japan I ADC 105 Large 15% Tumor tissue IHC 9 Multivariate DFS
Lei 2013 [69] China I-IV NSCLC 279 Large 30% Tumor tissue IHC 9 Multivariate OS
Berghoff 2013 [36] Austria I-IV NSCLC 230 Large 40% Tumor tissue IHC 9 Multivariate OS
Ji 2013 [61] China I-III NSCLC 67 Small 5% Tumor tissue IHC 9 Multivariate OS
Kobyakov 2013 [68] USA I-III SQC 118 Large 30% Tumor tissue IHC 7 Survival curve OS
Zu 2013 [117] China I-III ADC 96 Small 25% Tumor tissue IHC 7 Survival curve OS
Liu 2013 [70] China I-III NSCLC 105 Large 50% Tumor tissue IHC 8 Multivariate OS
Hokka 2013 [53] Japan I-IV ADC 125 Large NA Tumor tissue IHC 9 Multivariate OS
Xue 2013 [73] China I-III NSCLC 83 Small 50% Tumor tissue IHC 8 Multivariate OS
Zhong 2014 [115] China I-IV NSCLC 270 Large 50% Tumor tissue IHC 8 Multivariate OS
Ahn 2014 [32] Korea I-III NSCLC 108 Large 40% Tumor tissue IHC 9 Multivariate DFS
Shimizu 2014 [93] Japan I-III SQC 32 Small 10% Tumor tissue IHC 8 Multivariate DFS
Shimizu 2014 [93] Japan I-III ADC 52 Small 10% Tumor tissue IHC 8 Multivariate DFS
Kim 2014 [136] Korea I-IV ADC 122 Large 10% Tumor tissue IHC 7 Univariate OS
Tsoukalas 2014 [95] Greece I-IV NSCLC 112 Large NA Tumor tissue IHC 9 Multivariate OS
Kawatsu 2014 [63] Japan I-IV NSCLC 183 Large 10% Tumor tissue IHC 8 Multivariate OS
Corzani 2014 [39] Italy III NSCLC 50 Small 50% Tumor tissue IHC 8 Multivariate OS
Warth 2014 [18] Germany I-IV ADC 482 Large 25% Tumor tissue IHC 7 Univariate OS and DFS
Warth 2014 [18] Germany I-IV SQC 233 Large 50% Tumor tissue IHC 8 Multivariate OS
Tabata 2014 [25] Japan I-IV NSCLC 74 Small 10% Tumor tissue IHC 9 Multivariate OS
Xu 2014 [108] China I-IV ADC 80 Small 5% Tumor tissue IHC 7 Survival curve OS
Liu 2014 [70] China I-IV NSCLC 96 Small 30% Tumor tissue IHC 7 Survival curve OS
Ji 2014 [60] China I-III NSCLC 83 Small NA Tumor tissue IHC 8 Multivariate OS
Shimizu 2014 [93] Japan I-IV SQC 32 Large 10%% Tumor tissue IHC 9 Multivariate OS
Shimizu 2014 [93] Japan I-IV ADC 52 Large 10%% Tumor tissue IHC 9 Multivariate OS
Kobierzycki 2014 [67] Poland I-IV NSCLC 218 Large 25% Tumor tissue IHC 6 Univariate OS
Xu 2014 [107] China I-III NSCLC 114 Large 50% Tumor tissue IHC 7 Univariate OS
Zhang 2015 [114] China I-IV ADC 616 Large NA Tumor tissue IHC 8 Multivariate OS
Gobbo 2015 [40] Italy NA NSCLC 383 Large 20% Tissue microarray IHC 7 Univariate OS
Stewart 2015 [123] USA II-IIIA NSCLC 230 Large NA Tumor tissue IHC 7 Univariate DFS
Vigouroux 2015 [96] France I-IV NSCLC 190 Large 40% Tumor tissue IHC 7 Survival curve OS
Jethon 2015 [59] Poland I-IV SQC 89 Small 25% Tumor tissue IHC 7 Univariate OS
Jethon 2015 [59] Poland I-IV ADC 98 Small 25% Tumor tissue IHC 7 Univariate OS
Apostolova 2016 [35] Germany I-IV NSCLC 83 Small 75% Tumor tissue IHC 8 Multivariate OS
Cardona 2016 [38] USA NA NSCLC 144 Large 30% Tumor tissue IHC 7 Original data OS