Table 1 Characteristics of studies included into the meta-analysis
Study(author/year) | Region | Tumor stage | Histological type | Patients | Sample size | Cutoff value | Sample type | Assay | NOS score | Extract method | Survival |
|---|---|---|---|---|---|---|---|---|---|---|---|
Scagliotti 1993 [91] | Italy | I-IIIA | NSCLC | 111 | Large | 25% | Tumor tissue | IHC | 7 | Survival curve | OS |
Pence 1993 [120] | USA | I-IV | NSCLC | 61 | Small | 4% | Tumor tissue | IHC | 7 | Survival curve | OS |
Fontanini 1996 [46] | Italy | NA | NSCLC | 70 | Small | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Bohm 1996 [37] | Germany | NA | SCLC | 32 | Small | 27% | Tumor tissue | IHC | 7 | Original data | OS |
Harpole 1996 [50] | USA | I | NSCLC | 275 | Large | 7% | Tumor tissue | IHC | 9 | Multivariate | OS |
Pujoll 1996 [88] | France | I-IV | LC | 97 | Small | NA | Tumor tissue | IHC | 7 | Survival curve | OS |
Mehdi 1999 [119] | USA | I-IV | NSCLC | 203 | Large | 25% | Tumor tissue | IHC | 9 | Multivariate | OS and DFS |
Demarchi 1999 [41] | Brazil | I-III | ADC | 64 | Small | 22% | Tumor tissue | IHC | 7 | Original data | OS |
Dingemans 1999 [42] | Netherland | I-III | SCLC | 93 | Small | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Wang 1999 [99] | China | NA | NSCLC | 85 | Small | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Shiba 2000 [92] | Japan | I-III | NSCLC | 95 | Small | 20% | Tumor tissue | IHC | 7 | Univariate | OS |
Hommura 2000 [54] | Japan | I-II | SQC | 91 | Small | 30% | Tumor tissue | IHC | 9 | Multivariate | OS |
Hommura 2000 [54] | Japan | I-II | NSCLC | 124 | Large | 30% | Tumor tissue | IHC | 9 | Multivariate | OS |
Nguyen 2000 [80] | Czech Republic | I-IV | NSCLC | 89 | Small | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Puglisi 2001 [87] | Italy | I-III | NSCLC | 81 | Small | 30% | Tumor tissue | IHC | 9 | Multivariate | OS |
Hayashi 2001 [52] | Japan | I-IV | NSCLC | 98 | Small | 13% | Tumor tissue | IHC | 9 | Multivariate | OS |
Pelosi 2001 [84] | Italy | I | SQC | 119 | Large | NA | Tumor tissue | IHC | 9 | Multivariate | OS and DFS |
Ramnath 2001 [121] | USA | I-IV | NSCLC | 160 | Large | 24% | Tumor tissue | IHC | 7 | Univariate | OS |
Ramnath 2001 [121] | USA | I-IV | NSCLC | 41 | Small | 50% | Tumor tissue | IHC | 7 | Univariate | OS |
Wang 2001 [101] | China | I-IV | LC | 166 | Large | 18% | Tumor tissue | IHC | 7 | Survival curve | OS |
Mojtahedzadeh 2002 [78] | Japan | I-III | ADC | 141 | Large | 10% | Tumor tissue | IHC | 8 | Multivariate | OS |
Minami 2002 [76] | Japan | I | ADC | 47 | Small | 20% | Tumor tissue | IHC | 8 | Multivariate | OS |
Takahashi 2002 [94] | Japan | I-IV | NSCLC | 62 | Small | 25% | Tumor tissue | IHC | 9 | Multivariate | DFS |
Wakabayashi 2003 [97] | Japan | I-IV | NSCLC | 140 | Large | 13% | Tumor tissue | IHC | 9 | Multivariate | OS |
Pelosi 2003 [85] | UK | I | ADC | 96 | Small | NA | Tumor tissue | IHC | 9 | Multivariate | OS |
Haga 2003 [49] | Japan | I | ADC | 58 | Small | 10% | Tumor tissue | IHC | 9 | Multivariate | OS |
Hashimoto 2003 [51] | Japan | I-III | ADC | 122 | Large | 20% | Tumor tissue | IHC | 8 | Multivariate | OS |
Poleri 2003 [86] | Argentina | I | NSCLC | 50 | Small | 67% | Tumor tissue | IHC | 7 | Survival curve | DFS |
Matheus 2004 [75] | Brazil | I-III | ADC | 33 | Small | 22% | Tumor tissue | IHC | 7 | Original data | OS |
Niemiec 2004 [81] | Poland | I-III | SQC | 78 | Small | 28% | Tumor tissue | IHC | 7 | Survival curve | OS |
Ahn 2004 [33] | Korea | II-IIIA | NSCLC | 65 | Small | 15% | Tumor tissue | IHC | 9 | Multivariate | OS |
Huang 2005 [55] | Japan | I | NSCLC | 97 | Small | 25% | Tumor tissue | IHC | 8 | Multivariate | OS |
Gasinska 2005 [48] | Poland | I-III | SQC | 81 | Small | 39% | Tumor tissue | IHC | 9 | Multivariate | OS |
Wang 2005 [100] | China | I-III | NSCLC | 51 | Small | 5% | Tumor tissue | IHC | 7 | Survival curve | OS |
Dong 2005 [43] | Japan | I-IV | ADC | 131 | Large | 18% | Tumor tissue | IHC | 9 | Multivariate | OS |
Niemiec 2005 [81] | Poland | I-III | SQC | 78 | Large | 28% | Tumor tissue | IHC | 7 | Survival curve | OS |
Huang 2005 [55] | Japan | II-III | NSCLC | 76 | Small | 25% | Tumor tissue | IHC | 8 | Multivariate | OS |
Tsubochi 2006 [64] | Japan | I-III | NSCLC | 219 | Large | 20% | Tumor tissue | IHC | 9 | Multivariate | OS |
Yang 2006 [110] | USA | I-III | NSCLC | 128 | Large | 25% | Tumor tissue | IHC | 9 | Multivariate | OS |
Nozawa 2006 [82] | Japan | IV | ADC | 35 | Small | 40% | Tumor tissue | IHC | 7 | Survival curve | OS |
Maddau 2006 [118] | Italy | II-III | NSCLC | 88 | Large | 25% | Tumor tissue | IHC | 7 | Univariate | OS |
Maddau 2006 [118] | Italy | I | NSCLC | 92 | Large | 25% | Tumor tissue | IHC | 7 | Univariate | OS |
Inoue 2007 [58] | Japan | I-III | ADC | 97 | Small | 5% | Tumor tissue | IHC | 9 | Multivariate | DFS |
Mohamed 2007 [77] | Japan | I-IV | NSCLC | 61 | Small | 20% | Tumor tissue | IHC | 9 | Multivariate | OS |
Zhou 2007 [116] | China | I-II | NSCLC | 70 | Small | NA | Tumor tissue | IHC | 6 | Multivariate | OS |
Morero 2007 [79] | Argentina | III | NSCLC | 32 | Small | 66% | Tumor tissue | IHC | 7 | Survival curve | OS |
Yoo 2007 [112] | Korea | I-III | NSCLC | 219 | Large | 30% | Tumor tissue | IHC | 9 | Multivariate | OS |
Fujioka 2008 [47] | Japan | I | ADC | 73 | Small | 14% | Tumor tissue | IHC | 9 | Multivariate | OS |
Imai 2008 [57] | Japan | I | NSCLC | 248 | Large | 25% | Tumor tissue | IHC | 9 | Multivariate | OS |
Woo 2008 [103] | Japan | Ia | ADC | 131 | Large | 10% | Tumor tissue | IHC | 8 | Univariate | DFS |
Woo 2008 [103] | Japan | Ib | ADC | 59 | Small | 10% | Tumor tissue | IHC | 8 | Univariate | DFS |
Saad 2008 [89] | USA | I-III | NSCLC | 54 | Small | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Kaira 2008 [124] | Japan | I-III | NSCLC | 321 | Large | 25% | Tumor tissue | IHC | 9 | Multivariate | OS |
Ikeda 2008 [56] | Japan | I-III | NSCLC | 200 | Large | 5% | Tumor tissue | IHC | 7 | Univariate | OS and DFS |
Anami 2009 [34] | Japan | I-IV | ADC | 139 | Large | 10% | Tumor tissue | IHC | 8 | Multivariate | OS |
Yuan 2009 [113] | China | I-III | NSCLC | 140 | Large | 25% | Tumor tissue | IHC | 8 | Multivariate | OS |
Kaira 2009 [62] | Japan | 1 | ADC | 139 | Large | 20% | Tumor tissue | IHC | 9 | Multivariate | OS |
Erler 2010 [44] | USA | NA | SCLC | 68 | Small | 50% | Tumor tissue | IHC | 7 | Survival curve | OS |
Filipits 2011 [45] | Austria | I-III | NSCLC | 778 | Large | NA | Tumor tissue | IHC | 9 | Multivariate | OS and DFS |
Werynska 2011 [102] | Poland | I-IV | NSCLC | 145 | Large | 25% | Tumor tissue | IHC | 7 | Univariate | OS |
Yamashita 2011 [109] | Japan | I | NSCLC | 44 | Small | 5% | Tumor tissue | IHC | 8 | Multivariate | DFS |
Wu 2011 [106] | China | I-IV | NSCLC | 160 | Large | 10% | Tumor tissue | IHC | 8 | Multivariate | OS |
Oka 2011 [83] | Japan | I-III | ADC | 183 | Large | 20% | Tumor tissue | IHC | 9 | Multivariate | DFS |
Sterlacci 2011 [122] | Austria | I-IV | NSCLC | 386 | Large | 3% | Tumor tissue | IHC | 9 | Multivariate | OS |
Werynska 2011 [102] | Poland | NA | NSCLC | 145 | Large | 25% | Tumor tissue | IHC | 7 | Univariate | OS |
Liu 2012 [71] | China | I-IV | NSCLC | 494 | Large | 50% | Tumor tissue | IHC | 9 | Multivariate | OS |
Wang 2012 [98] | China | NA | SCLC | 42 | Small | 10% | Tumor tissue | IHC | 7 | Survival curve | OS |
Liu 2012 [71] | China | I-IV | ADC | 97 | Small | 10% | Tumor tissue | IHC | 7 | Survival curve | OS |
Wu 2012 [105] | China | I-IV | ADC | 309 | Large | 50% | Tumor tissue | IHC | 9 | Multivariate | OS |
Salvi 2012 [90] | Italy | I-III | NSCLC | 81 | Small | 15% | Tumor tissue | IHC | 9 | Multivariate | OS |
Yang 2012 [111] | China | I-III | NSCLC | 68 | Small | 38% | Tumor tissue | IHC | 7 | Survival curve | OS |
Wu 2013 [104] | China | I-IV | NSCLC | 192 | Large | 10% | Tumor tissue | IHC | 9 | Multivariate | OS and DFS |
Maki 2013 [74] | Japan | I | ADC | 105 | Large | 15% | Tumor tissue | IHC | 9 | Multivariate | DFS |
Lei 2013 [69] | China | I-IV | NSCLC | 279 | Large | 30% | Tumor tissue | IHC | 9 | Multivariate | OS |
Berghoff 2013 [36] | Austria | I-IV | NSCLC | 230 | Large | 40% | Tumor tissue | IHC | 9 | Multivariate | OS |
Ji 2013 [61] | China | I-III | NSCLC | 67 | Small | 5% | Tumor tissue | IHC | 9 | Multivariate | OS |
Kobyakov 2013 [68] | USA | I-III | SQC | 118 | Large | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Zu 2013 [117] | China | I-III | ADC | 96 | Small | 25% | Tumor tissue | IHC | 7 | Survival curve | OS |
Liu 2013 [70] | China | I-III | NSCLC | 105 | Large | 50% | Tumor tissue | IHC | 8 | Multivariate | OS |
Hokka 2013 [53] | Japan | I-IV | ADC | 125 | Large | NA | Tumor tissue | IHC | 9 | Multivariate | OS |
Xue 2013 [73] | China | I-III | NSCLC | 83 | Small | 50% | Tumor tissue | IHC | 8 | Multivariate | OS |
Zhong 2014 [115] | China | I-IV | NSCLC | 270 | Large | 50% | Tumor tissue | IHC | 8 | Multivariate | OS |
Ahn 2014 [32] | Korea | I-III | NSCLC | 108 | Large | 40% | Tumor tissue | IHC | 9 | Multivariate | DFS |
Shimizu 2014 [93] | Japan | I-III | SQC | 32 | Small | 10% | Tumor tissue | IHC | 8 | Multivariate | DFS |
Shimizu 2014 [93] | Japan | I-III | ADC | 52 | Small | 10% | Tumor tissue | IHC | 8 | Multivariate | DFS |
Kim 2014 [136] | Korea | I-IV | ADC | 122 | Large | 10% | Tumor tissue | IHC | 7 | Univariate | OS |
Tsoukalas 2014 [95] | Greece | I-IV | NSCLC | 112 | Large | NA | Tumor tissue | IHC | 9 | Multivariate | OS |
Kawatsu 2014 [63] | Japan | I-IV | NSCLC | 183 | Large | 10% | Tumor tissue | IHC | 8 | Multivariate | OS |
Corzani 2014 [39] | Italy | III | NSCLC | 50 | Small | 50% | Tumor tissue | IHC | 8 | Multivariate | OS |
Warth 2014 [18] | Germany | I-IV | ADC | 482 | Large | 25% | Tumor tissue | IHC | 7 | Univariate | OS and DFS |
Warth 2014 [18] | Germany | I-IV | SQC | 233 | Large | 50% | Tumor tissue | IHC | 8 | Multivariate | OS |
Tabata 2014 [25] | Japan | I-IV | NSCLC | 74 | Small | 10% | Tumor tissue | IHC | 9 | Multivariate | OS |
Xu 2014 [108] | China | I-IV | ADC | 80 | Small | 5% | Tumor tissue | IHC | 7 | Survival curve | OS |
Liu 2014 [70] | China | I-IV | NSCLC | 96 | Small | 30% | Tumor tissue | IHC | 7 | Survival curve | OS |
Ji 2014 [60] | China | I-III | NSCLC | 83 | Small | NA | Tumor tissue | IHC | 8 | Multivariate | OS |
Shimizu 2014 [93] | Japan | I-IV | SQC | 32 | Large | 10%% | Tumor tissue | IHC | 9 | Multivariate | OS |
Shimizu 2014 [93] | Japan | I-IV | ADC | 52 | Large | 10%% | Tumor tissue | IHC | 9 | Multivariate | OS |
Kobierzycki 2014 [67] | Poland | I-IV | NSCLC | 218 | Large | 25% | Tumor tissue | IHC | 6 | Univariate | OS |
Xu 2014 [107] | China | I-III | NSCLC | 114 | Large | 50% | Tumor tissue | IHC | 7 | Univariate | OS |
Zhang 2015 [114] | China | I-IV | ADC | 616 | Large | NA | Tumor tissue | IHC | 8 | Multivariate | OS |
Gobbo 2015 [40] | Italy | NA | NSCLC | 383 | Large | 20% | Tissue microarray | IHC | 7 | Univariate | OS |
Stewart 2015 [123] | USA | II-IIIA | NSCLC | 230 | Large | NA | Tumor tissue | IHC | 7 | Univariate | DFS |
Vigouroux 2015 [96] | France | I-IV | NSCLC | 190 | Large | 40% | Tumor tissue | IHC | 7 | Survival curve | OS |
Jethon 2015 [59] | Poland | I-IV | SQC | 89 | Small | 25% | Tumor tissue | IHC | 7 | Univariate | OS |
Jethon 2015 [59] | Poland | I-IV | ADC | 98 | Small | 25% | Tumor tissue | IHC | 7 | Univariate | OS |
Apostolova 2016 [35] | Germany | I-IV | NSCLC | 83 | Small | 75% | Tumor tissue | IHC | 8 | Multivariate | OS |
Cardona 2016 [38] | USA | NA | NSCLC | 144 | Large | 30% | Tumor tissue | IHC | 7 | Original data | OS |