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Fig. 7 | Respiratory Research

Fig. 7

From: PDGF-BB regulates the pulmonary vascular tone: impact of prostaglandins, calcium, MAPK- and PI3K/AKT/mTOR signalling and actin polymerisation in pulmonary veins of guinea pigs

Fig. 7

PCLS: PDGFR downstream-signalling: MAPK- and PI3K/AKT/PKB-pathway in PVs. a PDGF-BB-induced contraction depends on MAP2K: (■) no pre-treatment / 100 nM PDGF-BB (n = 4); (□) 50 μM PD98059 / 100 nM PDGF-BB (n = 4); (grey square) 5 μM U0126 / 100 nM PDGF-BB (n = 4). b PDGF-BB-induced contraction depends on p-38/MAPK: (■) no pre-treatment / 100 nM PDGF-BB (n = 4); (□) 5 μM SB203580 / 100 nM PDGF-BB (n = 4). c PDGF-BB-induced contraction is mediated via PI3K-α: (■) no pre-treatment / 100 nM PDGF-BB (n = 6); (□) 1 μM GSK 1059625 / 100 nM PDGF-BB (n = 6). d PDGF-BB-induced contraction does not interact with PI3K-γ: (■) no pre-treatment / 100 nM PDGF-BB (n = 5); (□) 1 μM AS252424 / 100 nM PDGF-BB (n = 5). e PDGF-BB-induced contraction depends on the AKT/PKB signalling: (■) no pre-treatment / 100 nM PDGF-BB (n = 4); (□ 10 μM 10-DEBC / 100 nM PDGF-BB (n = 4). a-e) Statistics was performed by a LMM. P < 0.05 are considered as significant: * p < 0.05, ** p < 0.01 and *** p < 0.001

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Respiratory Research

ISSN: 1465-993X

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