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Table 2 Pair wise comparison of BM and circulating inflammatory and repair markers (median [IQR] or mean ± SD) in the three groups studied. Bolded italic text highlights variables with statistically significant differences (p ≤ 0.05)

From: Bone marrow characterization in COPD: a multi-level network analysis

 

Never-smokers (n = 15)

Smokers (n = 10)

COPD (n = 35)

ANOVA (or KW) P Value

BM CHARACTERIZATION

 Immunophenotype

  CD3%

5.00 [5.00–6.00]

5.50 [3.30–7.00]

6.00 [4.00–9.50]

0.59

  CD5%

5.00 [5.00–6.00]

5.00 [3.00–7.00]

6.00 [4.30–9.80]

0.40

  CD7%

7.00 [5.30–8.00]

6.00 [4.00–9.00]

6.00 [5.00–9.80]

0.78

  CD10%

20.00 [13.00–26.00]

19.00 [15.00–28.50]

19.50 [15.80–25.80]

0.79

  CD19 + %

3.00 [2.00–4.50]

3.00 [2.00–6.30]

3.00 [2.00–4.00]

0.57

  CD19 + CD10 + %

2.00 [1.30–3.00]

0.50[0.50–2.50]

2.00 [1.00–2.00]

0.62

  CD33%

76.00 [68.50–80.00]

68.50 [61.30–79.00]

71.50 [65.00–80.00]

0.47

  CD13%

34.50 [30.00–39.50]

30.00 [20.00–40.00]

30.00 [25.00–33.00]

0.43

  CD14%

2.00 [1.30–3.80]

3.00 [2.00–4.00]

3.00 [2.00–4.00]

0.31

  CD15%

70.00 [57.50–75.00]

62.50 [56.30–73.80]

65.00 [60.00–70.00]

0.70

  CD117%

2.00 [1.50–2.00]

2.00 [2.00–2.80]

2.00 [2.00–2.80]

0.40

  CD34%

1.00 [1.00–2.00]

2.00 [1.00–2.80]

1.00 [1.00–2.00]

0.50

  DR%

8.00 [4.50–11.00]

9.50 [7.30–10.00]

8.00 [7.503–10.00]

0.81

  CD4%

3.00 [3.00–3.00]

3.00 [2.00–3.40]

3.50 [3.00–4.80]

0.24

  CD8%

2.00 [2.00–3.00]

2.00 [1.30–4.00]

3.00 [2.00–4.00]

0.66

  CD56%

1.00 [1.00–1.80]

1.00 [1.00–2.00]

1.00 [1.00–1.00]

0.83

  sCD64%

3.00 [1.50–5.00]

3.00 [2.00–4.00]

3.00 [2.00–4.00]

0.88

Progenitor cell surface markers

 CD34

  %

7.38 [2.28–16.23]

13.44 [10.50–18.02]

14.50 [9.83–24.10]

0.07

  MFI

164.60 [110.50–202.80]

118.03 [54.99–335.73]

92.65 [65.85–113.10]

0.09

 CD 34 + c-kit+

  %

76.40 [67.00–85.40]

65.98 [57.88–79.71]

81.90 [66.80–84.70]

0.41

  MFI

24.70 [19.60–39.65]

19.95 [15.85–70.73]

38.10 [24.80–55.40]

0.36

 CD 34 + Ki67+

  %

69.40 [30.30–77.40]

83.30 [59.99–97.64]

96.80 [73.30–97.90]

0.72

  MFI

31.80 [22.35–52.90]

28.00 [21.75–70.65]

50.30 [43.30–74.30]

0.32

 CD34 + 133 + KDR+

  %

1.10 [0.00–3.05]

1.23 [0.18–1.80]

4.35 [1.58–7.73]

0.51

  MFI

78.00 [37.93–127.15]

112.40 [74.48–134.73]

49.25 [40.10–120.60]

0.33

INFLAMMATORY AND REPAIR MARKERS

 BM Supernatant

  IL6 pg/ml

12.20 [1.30–23.00]

13.06 [1.65–27.39]

9.80 [7.60–24.90]

0.06

  IL-8 pg/ml

6.50 [3.90–10.70]

7.10 [3.00–8.70]

3.60 [2.40–10-90]

0.48

  HGF pg/ml

2854.07 [646.71–22,718.86]

1290.97 [909.37–9284.43]

1689.59 [692.43–2466.46]

0.63

 Circulating blood

  Leucocytes ×10^9/L

7.67 ± 3.43

8.41 ± 2.45

7.41 ± 1.88

0.52

  Neutrophils %

55.07 ± 18.58 *

71.98 ± 11.92

61.69 ± 11.85

0.02

  Eos %

2.13 ± 1.77

1.46 ± 1.19

3.14 ± 1.65

0.01

  CRP mg/dl

1.62 ± 2.05

0.90 ± 2.19

5.65 ± 12.57

0.02

  IL-6 pg/ml

0.10 [0.10–0.10]

0.10 [0.00–0.10]

0.10 [0.1–0.20]

0.14

  IL-8 pg/ml

1.40 [0.90–2.50]

2.80 [1.30–5.90]

2.30 [1.5–3.10]

0.82

  1. IL Interleukin, HCG Hepatocyte growth factor, MFI Mean fluorescence intensity; *P-value< 0.05 compared to never-smoking controls; P-value< 0.05 compared to smoking controls; P-value< 0.05 compared to never-smoking and smoking controls