Uric acid, lung function, physical capacity and exacerbation frequency in patients with COPD: a multi-dimensional approach

Table 2 Results of the final path analysis model

Regression			Estimate	S.E.	C.R.	Standardized	P
Uric acid	←	BMI	.079	.006	12.631	0.273	p < 0.001
Uric acid	←	Packyears	.052	.013	4.058	0.088	p < 0.001
Uric acid	←	Age	.019	.004	4.903	0.105	p < 0.001
CV comorbidity	←	Uric acid	.054	.015	3.674	0.083	p < 0.001
CV comorbidity	←	Age	.024	.003	9.235	0.201	p < 0.001
CV comorbidity	←	BMI	.033	.004	7.722	0.173	p < 0.001
FEV₁	←	Age	.306	.051	6.009	0.137	p < 0.001
FEV₁	←	Uric acid	−0.790	.284	−2.781	−0.065	0.005
FEV₁	←	BMI	.565	.083	6.813	0.160	p < 0.001
FEV₁	←	CV comorbidity	−1.294	.437	−2.963	−0.069	0.003
Exacerbations	←	FEV₁	−.006	.001	−10.937	−0.240	p < 0.001
Exacerbations	←	CV comorbidity	.033	.011	3.067	0.067	0.002
6-MWD	←	Uric acid	−6.090	1.376	−4.425	−0.087	p < 0.001
6-MWD	←	FEV₁	2.573	.113	22.856	0.448	p < 0.001
6-MWD	←	Age	−3.025	.249	−12.168	−0.236	p < 0.001
6-MWD	←	BMI	−3.816	.406	−9.402	−0.187	p < 0.001
6-MWD	←	Exacerbations	−22.530	4.276	−5.268	−0.102	p < 0.001
6-MWD	←	CV comorbidity	−7.578	2.120	−3.575	−0.070	p < 0.001
Covariances			Estimate	S.E.	C.R.	Standardized	P
Age	↔	Packyears	1.152	.475	2.428	0.055	p < 0.015
BMI	↔	Packyears	1.539	.302	5.102	0.116	p < 0.001

The upper panel refers to the directed arrows (regression terms) depicted in Figs. 2 and 3, whereby the left part lists the arrows shown in these figures. The right part shows the results of the corresponding statistical tests. The first column of the right part shows the non-standardized estimate of the respective regression coefficient, the second column the standard error (S.E.) of this coefficient, the third column the ratio of these two values (critical ratio, C.R.) which is used for significance testing. The forth column shows the standardized estimates of the regression coefficients shown in the first column. The last column shows the significance level based on the generalized least squares (GLS) procedure of AMOS. In an analogous manner the lower panel shows the covariances (bidirectional arrows in Figs 2 and 3) between risk factors, as well as the respective standard errors, critical ratios, correlation coefficients and significance levels

ISSN: 1465-993X