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Table 2 Relationship between serum bilirubin and lung function according to smoking status

From: Association of serum bilirubin level with lung function decline: a Korean community-based cohort study

Lung function parameters Bilirubin (Quintiles) Bilirubin (Continuous)
Quintile I Quintile 2 Quintile 3 Quintile 4 Quintile 5 P for Trend ß ± SE P-value
FEV1, L
 Continuous smoker 3.02 ± 0.62 3.17 ± 0.66 3.3 ± 0.62 3.44 ± 0.57 3.44 ± 0.6 0.048 0.09 ± 0.05 0.061
 Former smoker 3.04 ± 0.69 3.21 ± 0.71 3.33 ± 0.64 3.43 ± 0.62 3.48 ± 0.61 0.193 0.02 ± 0.05 0.619
 Never smoker 2.5 ± 0.51 2.57 ± 0.53 2.67 ± 0.55 2.77 ± 0.59 2.95 ± 0.64 < 0.001 0.10 ± 0.03 < 0.001
FVC, L
 Continuous smoker 3.95 ± 0.83 4.19 ± 0.79 4.3 ± 0.72 4.37 ± 0.68 4.38 ± 0.67 0.262 0.04 ± 0.06 0.441
 Former smoker 3.94 ± 0.75 4.08 ± 0.79 4.21 ± 0.69 4.37 ± 0.69 4.32 ± 0.64 0.454 −0.02 ± 0.06 0.772
 Never smoker 3.08 ± 0.6 3.16 ± 0.64 3.31 ± 0.98 3.39 ± 0.73 3.61 ± 0.79 0.018 0.10 ± 0.04 0.012
FEV1/FVC, %
 Continuous smoker 77.11 ± 7.71 76.42 ± 8.51 77.39 ± 7.63 78.54 ± 7.97 79.35 ± 7.48 0.205 1.02 ± 0.64 0.109
 Former smoker 76.98 ± 9.09 77.85 ± 8.49 78.26 ± 8.01 78.88 ± 6.54 79.6 ± 7.27 0.516 0.52 ± 0.65 0.423
 Never smoker 81.36 ± 6.68 81.62 ± 6.39 81.53 ± 6.37 81.99 ± 6.28 81.96 ± 6.16 0.027 0.76 ± 0.41 0.061
FEF25–75%, L/s
 Continuous smoker 2.88 ± 1.15 2.98 ± 1.23 3.16 ± 1.21 3.43 ± 1.34 3.97 ± 8.54 0.063 0.53 ± 0.39 0.176
 Former smoker 2.83 ± 1.14 3.05 ± 1.18 3.26 ± 1.3 3.4 ± 1.19 3.53 ± 1.27 0.267 0.06 ± 0.10 0.534
 Never smoker 2.77 ± 0.97 2.85 ± 0.91 2.97 ± 0.95 3.1 ± 1.02 3.28 ± 1.06 < 0.001 0.18 ± 0.06 0.001
  1. Notes: Data are presented as the mean ± standard deviation. Bilirubin was analyzed across quintiles and as a continuous variable
  2. P-value for linear trend analysis adjusted for age, sex, and body mass index
  3. Abbreviations: SE standard error, FEV 1 forced expiratory volume in 1 s, FVC forced vital capacity, FEF 25–75% forced expiratory flow between 25 and 75% of vital capacity