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Fig. 6 | Respiratory Research

Fig. 6

From: Rapid clearance of heavy chain-modified hyaluronan during resolving acute lung injury

Fig. 6

Effect of TSG-6 deficiency on severity and resolution of LPS induced ALI. a. Daily weight loss over six days following LPS instillation shown as % change from baseline (mean +/− SD). b-f. Total bronchoalveolar lavage counts of CD45+ leukocytes, Ly6G+ neutrophils, CD11b+ macrophages, CD4+ T-cells, and CD8+ T-Cells determined by flow cytometry following PBS or LPS instillation for the indicated time. g-h. Levels of albumin and RAGE in bronchoalveolar lavage were determined by ELISA for mice treated with PBS or LPS. i. Lung injury scores were calculated from hematoxylin and eosin stained lung sections to assess the rate of ALI resolution in TSG-6 KO and WT mice treated with LPS. n = 3–7 per group. ANOVA with Tukey’s multiple comparisons. **P < 0.01, ****P < .0001. SD, standard deviation

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