Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Fig. 6 | Respiratory Research

Fig. 6

From: Hypoargininemia exacerbates airway hyperresponsiveness in a mouse model of asthma

Fig. 6

Similar prevalence of inflammatory cells in the lungs of asthmatic hypoargininemic and control mice. F/A2wt/wt and F/A2tg/tg mice were either mock-sensitized with PBS and challenged with OVA (PBS/OVA) or sensitized and challenged with OVA (OVA/OVA) as indicated. Panel a, top row: H&E-stained sections of the peribronchiolar region of the lung; middle row: mMBP-positive (eosinophilic) cells; bottom row: MPO-positive (neutrophilic) cells. Panel S: quantification in the sections of inflammatory cells in OVA-OVA-treated F/A2wt/wt (white diamonds) and F/A2tg/tg mice (black diamonds). The sections that were compared were stained simultaneously. Inflammatory scores were analyzed per lung region, i.e. peribronchiolar, parenchymal and perivenous (around the lung veins), and scored on a scale from 0 to 3 by two independent observers. Medians and quartiles of 7–8 mice per group are shown (when not drawn, quartiles coincide with medians). No differences in inflammatory scores were found

Back to article page