Table 1 Demographic characteristics of subject groups
Variable | COPD n = 85 | α1ATD n = 12 | Smokers n = 12 | Never smokers n = 12 | |
|---|---|---|---|---|---|
Demographics | |||||
Age (years) | 68 ± 8 | 62 ± 8* | 62 ± 6* | 69 ± 7 | |
Gender (% male) | 67 | 73 | 58 | 83 | |
BMI (kg/m2) | 25.9 ± 3.9 | 25.0 ± 3.3 | 23.1 ± 2.3* | 26.6 ± 2.6 | |
Current smoker n (%) | 11 (13)*** | 2 (17)*** | 12 (100)*** | 0 | |
Pack years smoked | 45 ± 25*** | 19 ± 11*** | 37 ± 19*** | 0 | |
Statin therapy n (%) | 26 (31)* | 0*** | 0*** | 2 (17) | |
Lung function | |||||
FEV1 (L) | 1.37 ± 0.6*** | 1.47 ± 0.4*** | 2.84 ± 0.6 | 2.88 ± 0.6 | |
FEV1% predicted | 51 ± 20*** | 45 ± 16*** | 95 ± 17 | 100 ± 15 | |
GOLD stage II/III (%) | 77 | 83 | – | – | |
Perc 15 score (HU) | − 890 ± 54*** | − 942 ± 18*** | −818 ± 23 | −806 ± 36 | |
Hemodynamic measurements | |||||
SBP (mmHg) | 137 ± 18 | 132 ± 11 | 134 ± 16 | 131 ± 8 | |
DBP (mmHg) | 79 ± 7 | 84 ± 8 | 84 ± 7 | 79 ± 7 | |
Heart rate (bpm) | 71 ± 18 | 76 ± 10 | 67 ± 16 | 66 ± 10 | |
Aortic pulse wave velocity (m/s) | 9.9 ± 2.6* | 9.5 ± 1.8* | 7.8 ± 1.8 | 7.9 ± 1.7 | |
Laboratory data | |||||
Fibrinogen (g/L) | 3.4 ± 0.7* | 3.1 ± 0.6 | 2.8 ± 0.6 | 2.7 ± 0.5 | |
hsCRP (mg/L) | 5.2 ± 7.0* | 3.3 ± 2.3* | 2.1 ± 1.4 | 1.2 ± 0.6 | |
White cell count (×109/L) | 6.54 ± 1.83 | 7.01 ± 2.72 | 7.28 ± 2.02 | 5.84 ± 1.31 | |
Neutrophils (×109/L) | 4.43 ± 3.6 | 4.68 ± 2.47 | 4.53 ± 1.45 | 3.63 ± 1.11 | |
LDL Cholesterol (mmol/L) | 2.9 ± 1.0 | 3.54 ± 0.4 | 3.1 ± 1.1 | 3.1 ± 1.1 | |
Total/HDL Cholesterol (mmol/L) | 3.5 ± 1.3 | 3.5 ± 1.3 | 3.5 ± 1.6 | 3.4 ± 1.2 | |
Triglycerides (mmol/L) | 1.4 ± 0.8 | 1.5 ± 1.0 | 1.2 ± 0.7 | 1.2 ± 0.5 | |