Fig. 2
From: Regulation of alveolar macrophage death in acute lung inflammation
Endocytosis of HMGB1 induces pyroptosis. HMGB1 acting through RAGE on macrophages triggers dynamin-dependent endocytosis of HMGB1, which in turn initiates a cascade of cellular and molecular events. These include CatB activation and release from ruptured lysosome followed by pyroptosome formation and caspase-1 activation, which serves as a mechanism underlying the HMGB1-induced pyroptosis (This figure is adapted from the Ref. [21]. Adapted with permission)