Fig. 6
From: Oxidative stress enhances the expression of IL-33 in human airway epithelial cells
Schematic representation of the effect of oxidative stress on IL-33 expression in airway epithelial cells. H2O2 potentiates the expression of IL-33 in human airway epithelial cells. H2O2 enhances the phosphorylation of MAPK (p38, JNK, ERK1/2) and a p38 MAPK inhibitor, SB203580, a JNK inhibitor, SP600125, and an ERK1/2 inhibitor, U0126 inhibits the expression of IL-33. Neither an IKK-2 inhibitor, SC-514 nor an IκBα inhibitor, BAY11-7085 affects the H2O2-augmented IL-33 expression. H2O2 potentiates the expression of IL-33 stimulated by TLR3 ligand, poly (I:C) and rhinoviral-infection, and the potentiation is inhibited by the antioxidant NAC. These data suggest that oxidative stress enhances the expression of IL-33 via MAPK pathway and the expression of IL-33 can be further increased in human airway epithelial cells during virus infections. NAC = N-acetylcysteine. BAY = BAY 11-7085